Searchable abstracts of presentations at key conferences in endocrinology

ea0063p430 | Adrenal and Neuroendocrine Tumours 2 | ECE2019

Efficacy of DHEA in improving Quality of Life in prolonged HPA axis suppression from exogenous steroids

Anandappa Samantha , Kumar Rakshit , Breen Louise , Thakali Sonu , Tam Maria , Magtoto Cynthia , Carroll Paul , Velusamy Anand

Dehydroepiandrosterone (DHEA) has been a subject of controversy for more than a decade being called ‘a miracle hormone’, the ‘elixir of life’ and ‘an anti-aging supplement’. However, recent literature has proven mild to moderate benefit in selected group of patients. Data is mostly limited to primary adrenal failure patients with adequate glucocorticoid and mineralocorticoid replacement and in hypopituitarism from variable aetiology associated wit...

ea0090p12 | Adrenal and Cardiovascular Endocrinology | ECE2023

HPA axis suppression in patients treated with glucocorticoids: relationship to dose, duration and likelihood of recovery

Gregori Maria , Carroll Paul , Thakali Sonu , Breen Louise , Velusamy Anand , McGowan Barbara , Kariyawasam Dulmini , Tremble Kathryn , Saqib Aaisha

Background: Tertiary adrenal insufficiency (TAI) is a complication of long-term exogenous steroid use which results in suppression of the hypothalamic-pituitary-adrenal (HPA) axis. The short synacthen test (SST) is used to assess HPA axis function and recovery during glucocorticoid weaning. This study examined the effect of steroid preparation, dosage and therapy duration on HPA axis suppression.Method: A retrospective analysis of 950 SSTs performed betw...

ea0094p337 | Endocrine Cancer and Late Effects | SFEBES2023

Pilot study of liquid biopsy in paragangliomas: a feasible alternative to tissue biopsy in inoperable and multifocal lesions?

White Gemma , Quinn Mark , Carroll Paul , Velusamy Anand , Thakali Sonu , J. Oakey Rebecca , Izatt Louise , Hassan Fahim-UI

Background: Phaeochromocytoma and paraganglioma (PPGL) are highly heritable, with 30-40% due to a germline pathogenic variant. An additional 40% of tumours will harbour a somatic variant. Understanding the variant status of a tumour enables molecular classification. Liquid biopsy offers a novel approach to non-invasive diagnostics by harnessing the ability to detect small amounts of circulating-free DNA (cfDNA) and performing genomic sequencing. There are few ...