Searchable abstracts of presentations at key conferences in endocrinology

ea0044p94 | Diabetes and Cardiovascular | SFEBES2016

Does precocious dexamethasone treatment advance fetal cardiac maturation?

Batchen Emma , Richardson Rachel , Thomson Adrian , Moran Carmel , Sooy Karen , Homer Natalie , Gray Gillian , Chapman Karen

Synthetic glucocorticoids are administered to pregnant women at risk of pre-term delivery to mature organs and improve neonatal survival. We have shown that glucocorticoid action is essential to mature the fetal heart. Here, we tested the hypotheses that antenatal glucocorticoid exposure, prior to the normal increase in glucocorticoid levels, will advance fetal heart maturation and this will depend on cardiovascular glucocorticoid receptor (GR).Male SMGR...