Searchable abstracts of presentations at key conferences in endocrinology

ea0056p615 | Endocrine Disruptors | ECE2018

Disruption of amelogenesis by Adult Exposure to Di(2-ethylhexyl) Phthalate in Mice

Babajko Sylvie , Bui Ai Thu , Houari Sophia , Houari Sophia , Berdal Ariane

MIH (Molar Incisor Hypomineralyzation) is a recently described enamel pathology that affects now 15 to 18% of children worldwide. Its prevalence increased similarly to other pathologies associated to exposure to Endocrine Disrupting Chemicals (EDCs). In addition, MIH affects selectively permanent first molars and incisors, the first developing teeth during the perinatal period also the time window with the highest susceptibility to EDCs. Our previous published data showed the ...

ea0041oc10.1 | Reproduction & Endocrine Disruption | ECE2016

Systemic enamel pathologies may be due to anti-androgenic effects of some endocrine disruptors

Jedeon Katia , Loiodice Sophia , Houari Sophia , Lenormand Manon , Berdal Ariane , Babajko Sylvie

There has been increasing concerns over the last 20 years about the potential adverse effects of endocrine disruptors (EDs). Anecdotally, molar incisor hypomineralization (MIH), a recently described enamel pathology, now affecting 15–18% of 6–9 years old children, is increasing concurrently with ED related pathologies. Our previous data show that bisphenol A (BPA) and vinclozolin, two anti-androgenic EDs, impact amelogenesis and enamel mineralization preferentially i...

ea0049gp142 | Female Reproduction | ECE2017

Steroid receptors involvement in enamel hypomineralization resulting from exposure to low-dose DEHP and bisphenol A

Ai Thu Bui , Houari Sophia , Loiodice Sophia , Jedeon Katia , Berdal Ariane , Babajko Sylvie

The environment has become increasingly contaminated by various pollutants including endocrine disrupting chemicals (EDCs). This has led to an increase in the incidence and gravity of known pathologies and the emergence of new ones, including dental pathologies as the Molar Incisor Hypomineralization (MIH). Among the thousands of EDCs, bisphenol A (BPA) and phthalates (DEHP) are widely used by the plastic industry and responsible to frequent contaminations. We previously showe...

ea0037gp.08.06 | Reproduction: Male and endocrine disruptors | ECE2015

Bisphenol A affects amelogenesis by modulating enamel key genes expression

Jedeon Katia , Houari Sophia , Mcalpin Blake , Loiodice Sophia , Berdal Ariane , Babajko Sylvie

Bisphenol A (BPA) is a widespread endocrine disruptor commonly used by plastic industries. More than 95% of the world population contains BPA (ng/ml) in biological fluids raising the question of its activity and potential adverse effects. Anecdotally, molar incisor hypomineralisation (MIH), an enamel pathology affecting 15–18% of children, is increasing concurrently with ED related pathologies. Our previous data show that BPA impacts amelogenesis and generate similar enam...