Endocrine Abstracts

Background: Opioid analgesics are commonly used for chronic non-cancer pain but may impair gonadal and adrenal axis function. We measured pituitary function, rates of hormone deficiency, sexual function and quality of life (QoL) in patients on oral or transdermal opioids versus age and sex-matched controls.Methods: Participants with chronic non-malignant pain receiving oral or transdermal opioids for more than six m...

Background: Opioid analgesics are commonly used for chronic non-cancer pain but may impair gonadal and adrenal axis function. We measured pituitary function, rates of hormone deficiency, sexual function and quality of life (QoL) in patients on oral or transdermal opioids versus age and sex-matched controls.Methods: Participants with chronic non-malignant pain receiving oral or transdermal opioids for more than six m...

Hypertonic saline stimulated copeptin measurements have recently been described for the diagnosis of central DI. A copeptin cut-off of > 4.9 pmol/l has a diagnostic accuracy of 96.5% for distinguishing primary polydipsia from central DI1. A copeptin assay has recently been established in our laboratory. Validation of hypertonic saline-stimulated copeptin concentrations in our local population is needed before this test can be used with confidence in patients pre...