Searchable abstracts of presentations at key conferences in endocrinology

ea0056gp214 | Reproduction | ECE2018

Sperm DNA fragmentation index as a promising predictive tool for male infertility diagnosis and treatment management

Santi Daniele , Spaggiari Giorgia , Simoni Manuela

Background: Conventional parameters evaluated in semen analysis show several limits in the diagnostic setting of male infertility and do not provide any useful prognostic tool for assisted reproductive technique (ART). On the contrary, the assessment of sperm DNA fragmentation (sDF) was proposed to discriminate fertile from infertile men and to predict the follicle stimulating hormone (FSH) treatment response in infertile men. However, a comprehensive evaluation thereof is not...

ea0081ep865 | Reproductive and Developmental Endocrinology | ECE2022

A new, accurate and time-saving, two-step intracavernosal injection procedure to diagnose psychological erectile dysfunction

Spaggiari Giorgia , Granata Antonio Raffaele Michele , Simoni Manuela , Santi Daniele

Background: The recognition of the erectile dysfunction (ED) pathogenesis is essential to identify the appropriate ED management. Since vascular ED (vED) could be a manifestation of a systemic arterial damage, the watershed in the ED diagnostic framework is the discrimination between psychological (pED) and vED. However, reliable tools to directly diagnose pED are currently lacking.Aim of the study: To identify which parameters could predict pED. Moreove...

ea0081ep868 | Reproductive and Developmental Endocrinology | ECE2022

The FSH administration to men with idiopathic infertility improves sperm DNA fragmentation index together with testosterone serum levels increase

Santi Daniele , Spaggiari Giorgia , Lispi Monica , Panagiotis Drakopoulos , Simoni Manuela

Background: Testicular overstimulation is the pursued therapeutic goal when exogenous follicle-stimulating hormone (FSH) is empirically administered to men with idiopathic infertility. Although a robust physiological rationale theoretically supports the FSH use in male idiopathic infertility, useful markers to evaluate its efficacy are still far from being detected. While pregnancy rate remains the strong outcome in couple infertility management, the identification of reliable...

ea0063p637 | Interdisciplinary Endocrinology 1 | ECE2019

Polyphenol health effects on cardiovascular and neurodegenerative disorders: a meta-analysis

Spaggiari Giorgia , Poti Francesco , Zimetti Francesca , Zanotti Ilaria , Santi Daniele

Background: Polyphenols are proposed as protective factors against the occurrence of degenerative diseases affecting several systems, such as cardiovascular and neurocognitive ones. The beneficial effect of polyphenol-enriched diets is assumed to be multifactorial, including direct antioxidant and anti-inflammatory properties, as well as the polyphenol-related capability to modulate lipid metabolism and gut microbiota function. However, the prediction of polyphenolsÂ’ impa...

ea0070aep786 | Reproductive and Developmental Endocrinology | ECE2020

Endogenous doping: Physical exercise acutely increases testosterone levels. Results from a meta-analysis

Santi Daniele , Spaggiari Giorgia , Barbonetti Arcangelo , D’Andrea Settimio

Background: Physical exercise represents the first-line therapy in the management of metabolic diseases, considering its beneficial properties on blood pressure, glyco-lipid profile, body composition and hormonal imbalances. On the other hand, testosterone is largely investigated in the setting of competitive sport, representing the main doping source. Although endogenous testosterone levels are demonstrated to be affected by both acute exercise and resistance training, the dy...

ea0081p83 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Menstrual cycle abnormalities as distinctive sign of type 1 diabetes mellitus: results from a meta-analysis

Corleto Rossella , Greco Carla , Cacciani Marta , Spaggiari Giorgia , Simoni Manuela , Santi Daniele

Background: Type 1 diabetes mellitus (T1DM) management profoundly changed across years, with increasing emphasis on stringent glycaemic control. While it is well demonstrated that the progressive improvement of glycaemic control allows a tighter command of diabetes-related complications, the positive implications thereof on reproductive functions are still unclear. Indeed, it is well known that oligomenorrhea and amenorrhea are more frequently detected in young women with T1DM...

ea0081p181 | Reproductive and Developmental Endocrinology | ECE2022

Hormonal treatment modification during the long term follow-up of transwomen and transmen individuals: a retrospective observational Italian study

Cacciani Marta , Spaggiari Giorgia , M. Granata Antonio R. , Simoni Manuela , Santi Daniele

Background: Persons with assigned either male (AMAB) or female (AFAB) sex at birth might wish to obtain feminization or masculinization, respectively. To this purpose, hormonal treatment with sex hormones must be tailored to each subject. Several studies and the European Society of Endocrinology guidelines tried to identify the optimal hormonal treatment in both AMAB and AFAB subjects. However, the clinical management in the long term follow-up remains challenging. Many treatm...

ea0081ep867 | Reproductive and Developmental Endocrinology | ECE2022

Real-world evidence of follicle stimulating hormone effectiveness in male idiophatic infertility

Romeo Marilina , Spaggiari Giorgia , Nuzzo Federico , R.M. Granata Antonio , Simoni Manuela , Santi Daniele

Introduction: Male idiopathic infertility represents a therapeutic challenge for physicians, since a targeted aetiological treatment does not exist. Several hormonal and non-hormonal therapies have been proposed so far to increase pregnancy rates. Among hormonal therapies, exogenous follicle-stimulating hormone (FSH) administration shows the most convincing physiological rationale in the face of a clinical efficacy below expectations. Indeed, from evidences available in the li...

ea0081ep896 | Reproductive and Developmental Endocrinology | ECE2022

Vascular erectile dysfunction as a mirror of general health: focus on patients comorbidities

Rossi Barbara , Romeo Marilina , Granata Antonio Raffaele Michele , Rochira Vincenzo , Simoni Manuela , Spaggiari Giorgia , Santi Daniele

Background: Erectile dysfunction (ED) represents the most frequent sexual dysfunction. Among several possible ED aetiologies, vascular ED (vED) presents the greatest implications for global individual health, resulting an early hallmark of cardiovascular diseases. Indeed, vED was demonstrated associated with a 1.25 times greater risk of developing major cardiovascular diseases. Alongside cardiovascular aspect, the evaluation of patients health, measured by the comorbidities nu...

ea0067o53 | Oral Presentations | EYES2019

Seasonal changes of serum gonadotropins and testosterone in men: a reappraisal from a large data set of real-world observations over eight years

Spaggiari Giorgia , Granata Antonio RM , Setti Monica , Tagliavini Simonetta , Trenti Tommaso , Simoni Manuela , Santi Daniele

Objective: Environmental rhythmicity seems able to affect the hypothalamic-pituitary-gonadal axis in animals, but the extent of its influence in humans is still controversial. This study was designed to evaluate seasonal fluctuations of the main hormones involved in the hypothalamic-pituitary-gonadal axis in men, using a big data approach.Methods: An observational, retrospective, big data trial was carried out, including all testosterone, luteinizing hor...