Searchable abstracts of presentations at key conferences in endocrinology

ea0013p122 | Cytokines and growth factors | SFEBES2007

Interleukin-1alpha: the key to polycystic ovarian syndrome?

Sathyapalan Thozhukat , Speirs Valerie , Killick Stephen , Atkin Stephen L

Polycystic ovary syndrome (PCOS) affects 5–10% of reproductive-aged women and is associated with hyperandrogenism and chronic anovulation. Leukocytes, together with granulosa cells, may contribute to the pathogenesis of PCOS via their ability to secrete an array of cytokines implicated in follicle growth.Aim: Using RT-PCR, we screened for the expression of a range of cytokines in ovarian biopsies obtained from PCOS patients and normal individuals to...

ea0065p130 | Endocrine Neoplasia and Endocrine Consequences of Living with and Beyond Cancer | SFEBES2019

Nuclear receptor profiling predicts chemical disruptors as risk factors for developing breast cancer

Leif Freya , Pfander Pauline , Baker Syed Murtuza , Donaldson Ian , McGinnis Kathryn , Leslie Fiona , Thorne James , Cook Graham , Twelves Christopher , Speirs Valerie , Matthews Laura

Triple negative breast cancer (TNBC) represents 10–20% of all breast cancers diagnosed, affects young people and is highly aggressive. These tumours lack expression of the receptors that bind estrogen and progesterone and stratify patients for hormonal therapy. The only current therapeutic option for TNBC is chemotherapy which has limited efficacy, and therefore novel therapies are desperately needed. The receptors for estrogen and progesterone belong to the nuclear recep...