Searchable abstracts of presentations at key conferences in endocrinology

ea0029oc12.2 | Obesity Clinical | ICEECE2012

Lipid-induced insulin resistance is associated with a reduction of IGF1 bioactivity independent of changes in IGFBP-1 and -2 in humans

Arafat A. , Homssi S.v.G. , Weickert M. , Kraatz J. , Spranger J. , Frystyk J. , Pfeiffer A. , Mohlig M.

Objectives: Insulin interacts with the GH – insulin-like growth factor (IGF) system by a reciprocal regulation of IGF-binding proteins (IGFBPs) and GH, which in turn interact to regulate insulin sensitivity (IS). We previously showed that IGFBP-2 is involved in the insulin-induced reduction in IGF1 bioactivity. We here address the modulation of IGF1 bioactivity during acute lipid-induced insulin resistance.Methods: 18 healthy men (30.8±2.6 year...

ea0029p285 | Cardiovascular Endocrinology and Lipid Metabolism | ICEECE2012

Insulin mediates the glucagon-induced decrease in atrial natriuretic peptide: a randomized controlled trial

Arafat A. , Rudovich N. , Weickert M. , Adamidou A. , Spranger J. , Birkenfeld A. , Mohlig M. , Pfeiffer A.

Objectives: Atrial natriuretic peptide (ANP) is a cardiac hormone that is known to play an essential role in regulation of blood pressure and vascular endothelial function. However, the metabolic regulation of ANP is not fully understood. In patients with the metabolic syndrome, hyperglucagonemia is a common feature, besides hypertension and hyperinsulinemia. Our aim was to evaluate the impact of glucagon on proANP and the possible mechanisms underlying this effect.<p clas...

ea0026p344 | Obesity | ECE2011

The modulation of brain derived neurotrophic factor (bdnf) during exercise in obesity

Arafat A M , Brunelli A , Budde H , Adamidou A , Spranger J , Mohlig M , Pfeiffer A F H

Objectives: Brain Derived Neurotrophic Factor (BDNF) plays a fundamental role in regulation of metabolism and energy homeostasis. Low BDNF levels have been identified as possible biological causes for development of obesity and BDNF administration has been shown to induce weight loss and to improve insulin sensitivity in diabetic animal models. Acute exercise is known to induce a transient increase of peripheral BDNF but no information is yet available regarding the exercise-i...

ea0011p405 | Diabetes, metabolism and cardiovascular | ECE2006

Growth hormone and IGFBP-3 but not IGF-1 are independent predictors for insulin sensitivity in healthy subjects: on the role of hGH in the metabolic syndrome

Arafat MA , Perschel F , Schöfl C , Weickert M , Purschwitz J , Rochlitz H , Spranger J , Möhlig M , Pfeiffer AFH

Objectives: Insulin resistance (IR) and obesity are very common metabolic abnormalities, which are often associated with reduced GH secretion. GH reduces intraabdominal fat and its deficiency may contribute to the metabolic syndrome. IGF-1 improves IR but IGFBPs have a potential role in regulating its bioactivity although only little information exists. We postulate that the elevated insulin levels in IR may persistently suppress GH provided its regulation remains insulin sens...

ea0011p642 | Neuroendocrinology and behaviour | ECE2006

Glucagon-induced suppression of ghrelin secretion is exerted at hypothalamus-pituitary level and is not mediated by an increase in catecholamine secretion

Arafat MA , Perschel F , Otto B , Weickert M , Rochlitz H , Schöfl C , Spranger J , Möhlig M , Pfeiffer AFH

Objective: The mechanisms underlying the well known glucagon-induced satiety effect are unclear. We showed earlier that glucagon induces a remarkable decrease in the orexigenic hormone: ghrelin. It was the aim of the present study to further evaluate the effect of glucagon on ghrelin secretion and the possible site of origin of this effect.Methods: We studied the endocrine and metabolic responses to intramuscular glucagon administration in 23 subjects (1...