Searchable abstracts of presentations at key conferences in endocrinology

ea0104p194 | Reproductive Endocrinology | SFEIES24

Multi-receptor activation by (GIP-GCG-GLP-1) triple agonist regulates female reproductive function in diet induced obese mice

Sridhar Ananyaa , Khan Dawood , Flatt Peter , Moffett Charlotte

Background/Aims: Emerging evidence suggests that gut hormones interact with the reproductive axis and impact fertility in females. Here we combine three major gut hormones glucose-dependent insulinotropic peptide (GIP), glucagon (GCG) and glucagon-like peptide-1 (GLP-1), as a triple-agonist (TA) to elucidate its effects on female reproductive function.Methods: Female Swiss TO-mice (n = 6) on high-fat diet (HFD) or normal diet (ND) for 18-weeks r...

ea0104op4 | Oral Posters 1 – Endocrinology 1 | SFEIES24

GIP receptor agonist and antagonist alter testicular morphology and sperm parameters in high-fat diet fed obese mice

Khan Dawood , Sridhar Ananyaa , Komandur Vaishnavi , Gribble Fiona , Reimann Frank , Moffett Charlotte

Background: Glucose-dependent insulinotropic polypeptide (GIP) secreted by K-cells in the intestine is an incretin that stimulates insulin secretion from pancreatic beta-cells. The aim of this study is to explore the extra-pancreatic effects of GIP on male fertility using diet-induced obese mice.Methods: Male Swiss TO-mice (n = 8) on high-fat diet (HFD) or normal diet (ND) for 8-weeks received twice-daily intraperitoneal injections of (...

ea0104p191 | Reproductive Endocrinology | SFEIES24

Impact of synthetic estrogen ethinylestradiol on endometrial morphology and function in diet-induced obese mice

Mc Guigan Orla , Sridhar Ananyaa , Khan Dawood , Flatt Peter R. , Moffett Charlotte R.

Background/aims: Obesity is a major risk factor for endometrial cancer with estrogens in combined oral contraceptives enhancing the severity of the disease. This study aims to explore the effect of synthetic estrogen ethinylestradiol (EE2) commonly used in oral contraceptives, on endometrial morphology and regulatory markers in diet-induced obese mice.Methods: Female TO mice were on a high-fat diet (HFD) for 27 weeks. Three groups (n = 5) were g...