Searchable abstracts of presentations at key conferences in endocrinology

ea0082wd13 | Workshop D: Disorders of the adrenal gland | SFEEU2022

Male infertility in CAH – a balance of risk?

Naeem Ammara , Srirangalingam Umasuthan

26 year old gentleman with classic salt-wasting CAH due to 21-hydroxylase deficiency was maintained on hydrocortisone 7.5mg+7.5mg+5mg along with fludrocortisone 100 mg OD. Due to inadequate biochemical control, his hydrocortisone was increased to 10mg+10mg+5mg initially, which was subsequently switched to prednisolone 5mg+2.5mg. His 17-OH progesterone continued to remain high (300-400 nmol/l) with suppressed gonadotrophins and a high normal testosterone suggestive of mostly ad...

ea0013p158 | Diabetes, metabolism and cardiovascular | SFEBES2007

Modification of insulin receptor exon 11 alternative splicing by antisense oligonucleotides

Srirangalingam Umasuthan , Chew Shern L , Khoo Bernard

Introduction: There are two isoforms of the insulin receptor (IR), generated by the alternative splicing of exon 11 to give IR-A (exon 11-) and IR-B (exon 11+) isoforms. The differing distribution and function of the isoforms has been postulated to play a role in the pathogenesis of diabetes mellitus, myotonic dystrophy and thyroid carcinoma. Previous work investigating IR alternative splicing has identified hormonal factors, splicing elements and factors which modulate the re...

ea0055p36 | Poster Presentations | SFEEU2018

Severe necrotising pancreatitis secondary to hypertriglyceridaemia in pregnancy

Graham Julia , Gunganah Kirun , Williams David , Lunken Catherine , Srirangalingam Umasuthan

Case history: A 35-year-old woman with known hypertriglyceridaemia presented with a one day history of abdominal pain, vomiting and fever. She was 14 weeks pregnant having conceived spontaneously following a period of infertility. She had discontinued her lipid-lowering medication and was managed with diet alone. On examination, she was pyrexial, tachycardic (HR=100 bpm), normotensive (BP=111/71 mmHg), oxygen saturation was 96% on air and she had a tender distended abdomen. A ...

ea0048cp3 | Poster Presentations | SFEEU2017

Vitamin B very strong – complex endocrine dysfunction

Deore Mahesh , Stokes Felicity , Srirangalingam Umasuthan , Conway Gerard

A 40 years old man with a diagnosis of Adrenoleukodystrophy (ALD) was referred for evaluation of symptoms suggestive of hypogonadism. He had a past medical history of ALD associated adrenal insufficiency and osteoporosis. He took regular hydrocortisone and a trial medication, MD1003.Following review, post clinic blood tests revealed a testosterone 24.5 nmol/l (7.6–31.4), LH 8.8 IU/l (1.7–8.6) and FSH 1.5 IU/l (1.5–12.4). Thyroid function t...

ea0044p136 | Neoplasia, cancer and late effects | SFEBES2016

The role of primary cilia in the molecular pathogenesis of phaeochromocytoma

O'Toole Sam , Srirangalingam Umasuthan , Drake William , Chapple Paul

Phaeochromocytomas are life-threatening catecholamine-producing tumours of the adrenal medulla. Our understanding of their pathogenesis is incomplete, with limited ability to predict malignant potential and disappointing treatment results in disseminated disease. Phaeochromocytomas occur in the inherited cancer syndrome von Hippel-Lindau (VHL). One function of VHL protein is in the formation and maintenance of primary cilia. These are microtubule-based organelles that protrude...

ea0041gp1 | Adrenal | ECE2016

The role of primary cilia in the molecular pathogenesis of phaeochromocytoma

O'Toole Samuel , Srirangalingam Umasuthan , Drake William , Chapple J Paul

Phaeochromocytomas are neuroendocrine tumours arising from adrenal medulla chromaffin cells. They are life threatening due to adrenaline and noradrenaline release and potential for metastatic spread. Understanding of phaeochromocytoma pathogenesis is incomplete with limited ability to predict malignant potential. Additionally, once metastatic, response to conventional therapies is disappointing.Phaeochromocytomas are a common feature of the inherited can...

ea0038p155 | Neoplasia, cancer and late effects | SFEBES2015

Primary cilia: a new player in phaeochromocytoma pathogenesis?

O'Toole Sam , Srirangalingam Umasuthan , Drake William , Chapple Paul

Introduction: Primary, non-motile, cilia are microtubule-based organelles that protrude from the cell membrane into the extracellular environment of virtually all nucleated mammalian cells. They function as signalling platforms involved in the transduction of extracellular stimuli and have an important role in cell cycle regulation. Disruption of primary cilia structure and therefore function has been identified in a range of cancers including kidney, breast, pancreatic and pr...

ea0065p371 | Reproductive Endocrinology and Biology | SFEBES2019

Polycythaemia in a Klinefelter syndrome population on testosterone

Palan Jessal Mitul , Chung Teng-Teng , Simpson Helen , Baldeweg Stephanie , Srirangalingam Umasuthan

Background: Klinefelter syndrome (KS), karyotype 47XXY, affects 1 in 650 males. Subjects develop primary gonadal failure requiring life-long testosterone replacement. Many different testosterone formulations are available and long-term monitoring is necessary to avoid secondary polycythaemia.Objective: To investigate the effect of testosterone formulations used in KS subjects and estimate frequency of association with secondary polycythaemia.<p class...

ea0028p77 | Clinical practice/governance and case reports | SFEBES2012

Haemofiltration as a treatment for severe, resistant hypercalcaemia

Pittaway James , Raja Omair , O'Toole Sam , Gunganah Kirun , Srirangalingam Umasuthan , Hanson Philippa , Drake William

Introduction: We describe two patients admitted to our institution with severe hypercalcaemia, resistant to conventional treatment, requiring haemofiltration. Patient 1 was admitted to hospital with profound hypercalcaemia (5.8 mmol/L) secondary to primary hyperparathyroidism (PTH >263 Pmol/L). The hypercalcaemia had been discovered on a surgical admission 3 months previously and was being managed with 0.9% normal saline and pamidronate infusions at an outside hospital. On...

ea0025p187 | Endocrine tumours and neoplasia | SFEBES2011

Phaeochromocytoma, paraganglioma and tumour genetics: clinical practice lagging theory?

Srirangalingam Umasuthan , Sivathasan Nirupa , Akhtar Romaan , Berney Daniel , Maher Eamonn , Chew Shern

Background: Up to a third of subjects who develop a phaeochromocytoma or a paraganglioma will do so as the result of mutations in one of several familial genes. Identifying a causative mutation may have significant implications for family screening and future disease surveillance.Objective: To review the frequency and type of genetic testing undertaken in subjects presenting to our unit over a 20-year period who have developed a phaeochromocytoma and/or ...