Endocrine Abstracts

The suppression of serum TSH is a marker for increased risk of vascular mortality or death due to other causes are unknown. Nevertheless, patients who was operated on account of differentiated carcinoma of thyroid, had to take high doses of thyroxine for a long time to achieve suppression of TSH<0.1 mU/l. Heart rate variability (HRV), a method of mathematical analysis of heart rhythm (computer analysis of 24 h Holter monitoring), was used to assess function of the autonomi...

The transformation of toxic nodular goitre into autoimmune hyperthyroidism with development of thyrotropin receptor antibodies (TSHRAb) as effect of 131I therapy is rarely investigated.The aim of the study is to present cases of patients with toxic nodular goitre who developed autoimmune hyperthyroidism after initial 131I dose, and results of treatment with second 131I dose or thyrostatics.Four pati...

Abundant evidence indicates that the three deiodinases (D1, D2 and D3) function at the pre-receptor level to influence both extracellular and intracellular thyroid hormone levels and hence thyroid hormone action. Indirect evidence supports the concept that a major function of the D1 is to generate T3 for export to plasma whereas the D2 generates T3 primarily for local use. To obtain direct evidence concerning their individual physiological roles we have g...

Denosumab discontinuation (DD) induces an increase of B-crosslaps above baseline values for two years, and a decrease of BMD values. This rebound effect is associated with spontaneous clinical vertebral fractures (SCVF) in close to 15% of patients considering a follow-up of 2 years without taking another osteoporosis treatment. We report the clinical characteristics of 31 patients evaluated at our center from July 2015 to January 2018.Results: Thirty wom...

Introduction: Obesity increases the incidence of hypogonadism in men, and hypogonadism in turn plays a role in obesity. One of the first mechanisms proposed to explain this was a hypothesis based on the principle that obese men have higher estrogen levels, and that increased estrogens provide feedback to the hypothalamic-pituitary-testicular axis, reducing the secretion of gonadotropins and leading to a decrease of overall testosterone levels. This concept has since been quest...

Introduction: Acromegaly is a slowly progressing systemic disease that leads to numerous changes in metabolism and organ function. A large cross-sectional study showed signs of subclinical airway obstruction in female patients. We performed a longitudinal study of lung function testing to compare parameters of airway obstruction in male and female patients with acromegaly over time.Methods: 40 patients with acromegaly (24 male, 16 female) underwent repea...

Background: Apart from inactivation of the MEN1 gene, molecular events essential for tumorigenesis of the endocrine pancreas are poorly characterized. A potentially useful approach for understanding tumor progression is to study transcription factors operating in fetal pancreatic development. The Notch signaling cascade with expression of the transcription factors Hes1, Hey1, and Ascl1 plays a vital role in sustaining the balance between cell prolif...

Background & aim: Autoimmune thyroid disease (AITD) is frequently accompanied by other organ-specific diseases. The aim of this study was to estimate the frequency of the association AITD-Biermer’s disease (pernicious anemia) by investigating the presence of intrinsic factor antibodies (IF-Ab) in the serum of patients with AITD.Methods: Sera from patients with biological signs of AITD (increased serum TSH levels associated to detectable thyroid ...

Historically, acute neurosurgical decompression has been considered treatment of choice for pituitary apoplexy with some studies advocating a conservative approach. We describe a patient, with reduced consciousness due to apoplexy of a gonadotroph adenoma, in whom there was spontaneous tumour shrinkage. A 68-year-old gentleman presented following a collapse with hypothermia, bradycardia and bitemporal hemianopia. Initial investigations showed low plasma sodium and glucose. Ove...

The brain is critically involved in the regulation of energy balance and glucose homeostasis. Depending on the levels of energy available in our body, the activity of a group of hypothalamic neurons expressing the neuropeptidergic marker proopiomelanocortin (POMC) changes and it plays a key role in maintaining energy balance. When POMC neuronal activity is altered, this can lead to impaired energy homeostasis and therefore to obesity. However, POMC neurons are highly diverse, ...