Searchable abstracts of presentations at key conferences in endocrinology

ea0079021 | Abstracts | BES2021

Li-Fraumeni syndrome presenting as peripheral precocious puberty caused by a pure androgen-secreting adrenal adenoma

Sofie Ryckx , Jean De Schepper , Willem Staels

Introduction: Precocious puberty in boys is the development of secondary sexual characteristics before 9 years of age. Peripheral precocious puberty (PPP), as opposed to central precocious puberty (CPP), is caused by autonomous secretion of androgens or human chorionic gonadotropin (hCG). Testicular volume, penis size, growth velocity, gonadotropin and androgen levels, and bone age readings aid in diagnosing precocious puberty and in identifying its cause. Distinguishing CPP f...

ea0097010 | Section | BES2023

Cortical bone assessment and determinants in children and adolescents with Klinefelter syndrome

Maartje Hickmann , Elise Nauwynck , Caroline Ernst , Inneke Willekens , Jesse Vanbesien , Willem Staels , Schepper Jean De , Inge Gies

Aims: Several studies show a deficit in cortical bone in adults with Klinefelter syndrome (KS). A correlation between the adult cortical bone deficit and impaired bone accumulation during childhood or adolescence remains unclear. Therefore, we evaluated the cortical bone by automated digital X-ray radiogrammetry in KS children and adolescents and evaluated potential associations with hormonal, radiographic, and anthropometric factors implicated in bone mineral...

ea0057008 | Vegf-A mRNA transfection as a novel approach to improve mouse and human islet graft revascularization | BES2018

Vegf-A mRNA transfection as a novel approach to improve mouse and human islet graft revascularization

Willem Staels , Yannick Verdonck , Yves Heremans , Gunter Leuckx , Sofie De Groef , Carlo Heirman , Eelco de Koning , Conny Gysemans , Kris Thielemans , Luc Baeyens , Harry Heimberg , Nico De Leu

Aims/hypothesis: The initial avascular period following islet transplantation seriously compromises graft function and survival. Enhancing graft revascularization to improve engraftment has been attempted through virus-based delivery of angiogenic triggers, but risks associated with viral vectors have hampered clinical translation. In vitro transcribed mRNA transfection circumvents these risks and may be used for improving islet engraftment.Meth...