Searchable abstracts of presentations at key conferences in endocrinology

ea0029p1397 | Pituitary Clinical | ICEECE2012

Outcome of transsphenoidal surgery for Cushing’s disease dependent on tumor size: a single center experience

Dimopoulou C. , Stalla G.

Introduction: Transsphenoidal surgery (TSS) currently presents treatment of choice for Cushing’s disease (CD). Dependent on tumor size, remission rates after initial TSS range from 66 to 94%. In ACTH-secreting pituitary macroadenomas, remission rates are reported to be lower. Visible adenomas on preoperative MRI or intraoperatively and neurosurgical expertise might contribute to successful TSS.Design: A retrospective, single center analysis in 51 CD...

ea0026p295 | Pituitary | ECE2011

The dual PI3K/mTOR inhibitor NVP-BEZ235 has a potent antiproliferative action in human nonfunctioning pituitary adenomas

Cerovac V , Tichomirowa M , Stalla G , Theodoropoulou M

NVP-BEZ235 is an orally available ATP competitive inhibitor of class I PI3K and mTOR. As such it suppresses Akt phosphorylation downstreams to PI3K and to mTOR complex 2 in addition to p70/S6K1 phosphorylation downstreams to mTOR complex 1 and displays potent antiproliferative activity in tumors with dysregulated the PI3K/Akt pathway. Administration of NVP-BEZ235 in human nonfunctioning pituitary tumors in primary cell culture suppressed cell viability by more than 50% in 37 o...

ea0014p448 | (1) | ECE2007

Hyperprolactinemia in post-acute phase after severe TBI or SAH is mostly iatrogenic or due to physical stress

Kilimann Ingo , Stalla Günter Karl , von Rosen Friedrich

Background: Recent studies demonstrated partial or complete hypopituitarism in 30–70% of survivors of traumatic brain injury (TBI) and subarachnoid hemorrhage (SAH). Hyperprolactinemia may indicate damage of the pituitary stalk or the hypothalamus. Physical and psychological stress and a considerable list of medications can also lead to increased prolactin values.Methods: Prolactin was measured in 103 male and 54 female patients aged 14 to 89 years ...

ea0009p87 | Endocrine tumours and neoplasia | BES2005

Expression and role of 'steroid superfamily' receptors in meningioma

Bilko D , Renner U , Stalla G , Newton C

The meningioma is a tumour that arises from cells that form a fibrous membrane, covering the brain. They account for around 15percent of intracranial tumours and about 7percent of all people dying from brain tumours. These tumours occur more frequently in women than in men and this has lead to the suggestion that oestrogens have a role in their development and growth. Studies a decade ago with antioestrogens have proved inconclusive and therefore a medical therapy based on ant...

ea0029oc4.5 | Pituitary Basic | ICEECE2012

Targeting the IGF-IR system in pituitary tumors in vitro: antiproliferative action & pitfalls

Theodoropoulou M. , Tichomirowa M. , Cerovac V. , Monteserin J. , Rubinfeld H. , Stalla G.

IGF-I receptors (IGF-IR) and their aberrant signaling cascade contribute to the pathogenesis of several solid cancers. Pituitary adenomas express IGF-IR and present with overactivation of the IGF-IR pathway. The aim of the study was to identify the potential antiproliferative action of the small molecule IGF-IR inhibitor NVP-TAE226 on acromegalic (n=11) and nonfunctioning pituitary adenomas (NFPA; n=15) in primary cell culture. Changes in cell viability were dete...

ea0029oc10.2 | Pituitary Clinical 2 | ICEECE2012

Food intake regulating hormones in adult craniopharyngioma patients

Roemmler J. , Geigenberger V. , Otto B. , Bidlingmaier M. , Dimopoulou C. , Stalla G. , Schopohl J.

Introduction: Patients with craniopharyngeoma often have disturbances of the hypothalamic–pituitary axis and serious comorbidities as obesity. We hypothesized, that the pattern of hormones regulating the nutritional status is worsened in adult patients with craniopharyngioma (CP) compared to adult patients with non-functioning pituitary adenoma (NFPA).Methods: We included 33 patients with CP (m=16, f=17, median age: 48 years (26–7...

ea0029p1076 | Neuroendocrinology | ICEECE2012

Predictors of neuropsychiatric side effects of dopamine-agonist therapy in patients with prolactinomas

Athanasoulia A. , Sievers C. , Ising M. , Brockhaus A. , Yassouridis A. , Stalla G. , Uhr M.

Introduction: Treatment with dopamine agonists in patients with prolactinomas and Parkinson’s disease is associated with central side effects. Central side effects may depend on a substance’s ability to pass the blood-brain barrier which can be actively controlled by transporter molecules such as the P-glycoprotein encoded by the ABCB1 gene.Aim of the study: To determine whether cabergoline is transported by the P-glycoprotein and whether polym...

ea0029p97 | Adrenal cortex | ICEECE2012

Diagnosis of Cushing’s syndrome by automatic face classification using frontal and side-view photographs

Kosilek R. , Schopohl J. , Grunke M. , Dimopoulou C. , Stalla G. , Reincke M. , Gunther M. , Wurtz R. , Schneider H.

Background: Cushing’s syndrome is a disease that presents with clear symptoms and causes considerable harm to the body if left untreated, yet often remains undiagnosed for prolonged periods of time. Face-classification software might recognize typical changes of the face and thus aid in diagnosing the disease early as we have previously shown in the classification of acromegaly.Methods: Using a regular compact digital camera, we took frontal and sid...

ea0026p248 | Pituitary | ECE2011

Detection of acromegaly by automatic face classification software

Schneider H J , Kosilek R , Gunther M , Rommler J , Stalla G K , Sievers C , Reincke M , Schopohl J , Wurtz R

Acromegaly is accompanied by increased morbidity and mortality. The delay between onset of first symptoms and diagnosis of the disease is 6 to 10 years. Acromegaly causes typical changes of the face. We hypothesized that face classification software might help distinguishing between subjects with and without acromegaly on regular photographs and, thus, might help improving early recognition of acromegaly.Methods: We took frontal and side photographs of t...

ea0014oc8.3 | Neuroendocrinology clinical | ECE2007

Pituitary imaging abnormalities in patients with and without hypopituitarism after traumatic brain injury

Schneider Harald J. , Croce Chiara G. , Corneli Ginevra , Ghigo Ezio , Stalla Günter K. , Aimaretti Gianluca

Recent evidence shows that patients with traumatic brain injury (TBI) are at substantial risk of hypopituitarism. However, the pathomechanisms are still not completely understood. Little is known about the association of morphological changes in the sella region with pituitary function in TBI. In this study, we assessed morphological abormalities of the sella region in patients with TBI and their relation to endocrine function.We have studied MR or CT sc...