Endocrine Abstracts

Introduction: Data on the role of endogenous sex steroids in cerebrovascular disease is sparse. Our aim was to investigate the clinical relevance of circulating sex steroids in a postmenopausal acute stroke population and search for associations with disease severity and short-term outcome.Patients and methods: We prospectively studied 302 postmenopausal female patients hospitalized for an acute stroke in two tertiary hospitals, during a time period of 2...

Introduction: Several studies have examined the association of the common PvuII polymorphism of the estrogen receptor alpha (ERα) gene with the risk of stroke. Data linking the polymorphism with the severity and outcome of cerebrovascular disease is lacking. We looked for possible associations of the PvuII polymorphism with stroke severity and short-term prognosis in a cohort of female stroke patients.Patients-Methods: We studied 302 postmenopausal ...

Introduction: DHEAS is among the most abundant sex steroid products of the adrenal gland. DHEAS levels have been repeatedly associated with cardiovascular disease, but data concerning cerebrovascular disease, especially in women, is lacking. In this study, we aimed to investigate the role of DHEAS in a female population suffering an acute stroke.Patients and methods: We studied 302 consecutive female patients presenting with an acute stroke hospitalized ...

Introduction: Endogenous sex hormones may affect the cardiovascular risk profile in postmenopausal women indirectly by inducing metabolic, hemodynamic and immunological changes as well as directly through steroid receptors on the arterial wall. The results however, remain controversial.Objectives: This cross-sectional study aims to examine associations between circulating sex hormone levels and indices of vascular function and structure.<p class="abs...