Searchable abstracts of presentations at key conferences in endocrinology

ea0056gp87 | Diabetes Epidemiology | ECE2018

Differential expression of apoptotic and low grade inflammatory markers in Alzheimer’s disease compared to diabetes mellitus type 1 and 2

Alexandraki Krystallenia , Apostolopoulos Nikolaos , Adamopoulos Christos , Stamouli Evangelia , Dalagiorgou Georgia , Papaioannou Theodoros , Analitis Antonios , Karamanou Marianna , Makrilakis Konstantinos , Politis Antonios , Piperi Christina

Objective: Neuroinflammation is a common primary or secondary mediator of the neurodegenerative process accompanying Alzheimer’s disease (AD). Impaired brain insulin signaling, defining brain insulin resistance may represent a link between AD and type 2 diabetes mellitus (T2DM) while neuronal apoptosis may also be involved in the inflammatory process. Peripheral cytokine levels of IL-1β, IL-6, TNFα along with high sensitivity C-reactive protein (hsCRP) and apopt...