Searchable abstracts of presentations at key conferences in endocrinology

ea0049ep1184 | Neuroendocrinology | ECE2017

Prenatal testosterone exposure increases anxiety-like behavior in female rats

Rasic-Markovic Aleksandra , Macut Djuro , Hrncic Dragan , Cirkovic Valentina , Rankov-Petrovic Bojana , Sutulovic Nikola , Stanojlovic Olivera

Polycystic ovary syndrome (PCOS) is characterized by excessive androgen secretion and women with PCOS are at risk of developing anxiety disorders. Maternal testosterone levels in humans have been shown to affect brain development and to be correlated to mental function. During pregnancy, women with PCOS display high circulating androgen levels that may affect the fetus and increase the risk of mood disorders in offspring. This study investigated whether maternal androgen exces...

ea0049gp140 | Female Reproduction | ECE2017

Nonalcoholic fatty liver disease liver fat score (NAFLD-LFS) could be used for the assessment of NAFLD in women with PCOS

Bjekic-Macut Jelica , Bozic-Antic Ivana , Tziomalos Konstantinos , Ilic Dusan , Vojnovic-Milutinovic Danijela , Stanojlovic Olivera , Macut Djuro

Introduction: A relation between polycystic ovary syndrome (PCOS) and nonalcoholic fatty liver disease (NAFLD) was demonstrated recently. Both NAFLD and PCOS are associated with increased risk for type 2 diabetes and cardiovascular disease. NAFLD liver fat score (NAFLD-LFS) has been implicated as a non-invasive surrogate marker for NAFLD. The aim of this study was to identify the prevalence of NAFLD in different PCOS phenotypes using NAFLD-LFS.Methods: W...

ea0044p213 | Reproduction | SFEBES2016

The relation of liver enzymes and insulin resistance in women with polycystic ovary syndrome (PCOS)

Macut Djuro , Bozic-Antic Ivana , Tziomalos Konstantinos , Bjekic-Macut Jelica , Ilic Dusan , Vojnovic-Milutinovic Danijela , Stanojlovic Olivera , Panidis Dimitrios

Introduction: There is a link between polycystic ovary syndrome (PCOS) and nonalcoholic fatty liver disease (NAFLD). Here, we analyzed transaminazes and their relation to insulin resistance (IR) in PCOS women.Methods: We analyzed 600 women with PCOS diagnosed using ESHRE/ASRM criteria (age:25.6±5.9 years, BMI: 30.6±6.9 kg/m2), and 125 BMI-matched healthy controls (age: 31.4±5.3 years, BMI: 29.6±6.8 kg/m2). IR was...

ea0037gp.06.03 | Reproduction: Female and PCOS | ECE2015

Characteristics of lipid profile in different phenotypes of polycystic ovary syndrome

Bjekic-Macut Jelica , Antic Ivana Bozic , Milutinovic Danijela Vojnovic , Ilic Dusan , Kastratovic-Kotlica Biljana , Stanojlovic Olivera , Andric Zoran , Macut Djuro

Introduction: Dyslipidaemia is a common metabolic derangement in polycystic ovary syndrome (PCOS) and may be represented with different lipid alterations. The aim of this study was to evaluate lipid profile in different PCOS phenotypes.Methods: We evaluated 365 PCOS women (PCOS: 25.05±6.24 kg/m2; 25.48±5.21 years) diagnosed using ESHRE/ASRM criteria and 125 BMI-matched healthy women (controls: 25.41±5.16 kg/m2; 30.35&...

ea0035p625 | Female reproduction | ECE2014

Prevalence of dysglycaemia in obese women with polycystic ovary syndrome

Bjekic-Macut Jelica , Antic Ivana Bozic , Milutinovic Danijela Vojnovic , Stanojlovic Olivera , Kastratovic-Kotlica Biljana , Petakov Milan , Ilic Dusan , Macut Djuro

Introduction: Insulin resistance and obesity are common features of polycystic ovary syndrome (PCOS) and both are independently associated with dysglycaemia. The aim of this study was to determine prevalence of dysglycaemia in obese women with PCOS.Methods: PCOS was diagnosed using ESHRE/ASRM criteria. Obesity was defined as BMI ≥25 kg/m2. We evaluated 100 obese women with PCOS (PCOS group: 28.99±3.05 kg/m2; 27.70±5....

ea0056p949 | Female Reproduction | ECE2018

Association of hormonal and metabolic status with carotid intima-media thickness in women with polycystic ovary syndrome

Bjekic-Macut Jelica , Bozic-Antic Ivana , Erceg Snjezana , Civcic Milorad , Ilic Dusan , Vojnovic-Milutinovic Danijela , Stanojlovic Olivera , Macut Djuro

Introduction: Women with polycystic ovary syndrome (PCOS) have numerous risk factors that lead to higher risk for cardiovascular diseases (CVD) and stroke. Measurement of carotid intima-media thickness (CIMT) is a marker of CVD.Methods: We analyzed 399 women with PCOS diagnosed using ESHRE/ASRM criteria (age: 25.5±5.1 years, BMI: 24.9±6.2 kg/m2), and 82 BMI-matched healthy controls (age 29.2±5.9 years, BMI 25.3±8.6 kg/m<sup...

ea0081ep889 | Reproductive and Developmental Endocrinology | ECE2022

Association of SPISE and HOMA-IR indexes with metabolic characteristics of different age groups of women with polycystic ovary syndrome

Opalic Milica , Ognjanovic Sanja , Popovic Bojana , Ilic Dusan , Bjekic - Macut Jelica , Elezovic Valentina , Radic Lena , Milutinovic Danijela Vojnovic , Stanojlovic Olivera , Macut Djuro P.

Introduction: Polycystic ovary syndrome (PCOS) is the most prevalent endocrinopathy among women during reproductive age. PCOS cardinal manifestations include hyperandrogenism, oligo/anovulation, and/or polycystic ovarian morphology, and is closely linked to metabolic disorders such as obesity and insulin resistance (IR). It was observed that single-point insulin sensitivity estimator (SPISE) index is associated with metabolic abnormalities and could predict glucose regulation ...

ea0049gp139 | Female Reproduction | ECE2017

Sensitivity of hypothalamo-pituitary-adrenal axis in women with PCOS

Macut Djuro , Bozic-Antic Ivana , Bjekic-Macut Jelica , Ilic Dusan , Vojnovic-Milutinovic Danijela , Stanojlovic Olivera , Bogavac Tamara , Popovic Bojana , Isailovic Tatjana , Elezovic Valentina , Ognjanovic Sanja

Introduction: Increased adrenal androgen production is present in 20–60% of women with polycistic ovary syndrome (PCOS). Possible mechanism is not clarified yet and could be related to altered hypothalamic-pituitary-adrenal-axis (HPA) activity or a consequence of adrencortical steroidogenic abnormalities. The aim of the study was to assess HPA sensitivity in PCOS women using different doses of dexamethasone.Methods: We analyzed 359 women with PCOS d...

ea0049ep1114 | Female Reproduction | ECE2017

Novel insulin resistance index using C-peptide is reliable predictor of insulin resistance in women with PCOS

Bozic-Antic Ivana , Ilic Dusan , Bjekic-Macut Jelica , Vojnovic-Milutinovic Danijela , Ognjanovic Sanja , Bogavac Tamara , Popovic Bojana , Isailovic Tatjana , Elezovic Valentina , Stanojlovic Olivera , Macut Djuro

Introduction: Recently, it was suggested that insulin resistance index using C-peptide (CIR) could be a better marker of insulin resistance than homeostasis model assessment (HOMA-IR) in patients with type 2 diabetes mellitus. The aim of this study was to investigate performance of CIR index in PCOS subjects.Methods: We evaluated 187 PCOS women (PCOS: 25.38±6.32 kg/m2; 26.01±5.16 years) diagnosed using ESHRE/ASRM criteria and 42 heal...

ea0041ep667 | Female Reproduction | ECE2016

Glucose level after standard oral glucose tolerance test as a potential marker for the development of type 2 diabetes in women with polycystic ovary syndrome (PCOS)

Bozic-Antic Ivana , Bjekic-Macut Jelica , Ilic Dusan , Vojnovic-Milutinovic Danijela , Popovic Bojana , Bogavac Tamara , Isailovic Tatjana , Elezovic Valentina , Ognjanovic Sanja , Stanojlovic Olivera , Damjanovic Svetozar , Macut Djuro

Introduction: It has been shown that subjects with normal fasting glucose (NFG) and normal glucose tolerance (NGT), whose plasma glucose concentration does not return to their fasting plasma glucose (FPG) level within 2 h following standard oral glucose tolerance test (OGTT), have higher risk of progression into type 2 diabetes (T2D) than NFG/NGT subjects whose glucose returns to FPG level after OGTT. Although the development of T2D during the life of woman with polycystic ova...