Searchable abstracts of presentations at key conferences in endocrinology

ea0021p135 | Diabetes and metabolism | SFEBES2009

Testosterone replacement therapy has no effect on ultrasound assessed carotid artery stiffness and intima-media thickness in men with insulin treated type 2 diabetes

Stanworth Roger , Jones T Hugh

Context: Testosterone replacement therapy (TRT) has shown benefit on insulin resistance, glycaemic control and cardiovascular risk markers in hypogonadal men with diabetes. Arterial stiffness and intima-media thickness (IMT) are vessel wall properties associated with future cardovascular risk which allow the progress of atherosclerosis to be assessed non-invasively. Low testosterone has been associated with the presence and progression of carotid atherosclerosis as assessed by...

ea0063ep95 | Pituitary and Neuroendocrinology | ECE2019

Acute pituitary apoplexy-one year case series

Seifeldin Seifeldin , Ali Hisham , Stanworth Roger

Objectives: Pituitary Apoplexy, either as a result of haemorrhage or infarction, remains a rare but serious Endocrine Disorder, requiring urgent clinical assessment and management. The British Endocrine Society (BES) has set out recommendations regarding the diagnosis and management of pituitary apoplexy, but there remains little published literature depicting this. The aim of this study was to compare our current Management practise of Pituitary Apoplexy with the recommendati...

ea0044p118 | Diabetes and Cardiovascular | SFEBES2016

Retrospective review of insulin degludec (Tresiba) started in patients at Royal Derby Hospital

Yahia Seifeldin , Sahathevan Abhiram , Stanworth Roger

Introduction: Patients with diabetes mellitus require insulin with disease progression to attain or maintain glycaemic targets. Patients and physicians work together to balance the advantages of improved glycaemic control with the risk of hypoglycaemia and increasing regimen complexity. Insulin Degludec (Tresiba) is an ultra-long-acting insulin analogue launched in the UK in March 2013 and is available in two strengths, 100 and 200 units/ml.Method: Retro...

ea0091wd5 | Workshop D: Disorders of the adrenal gland | SFEEU2023

The impact of covid-19 infection on the diagnosis and management of adrenocortical carcinoma

van Heeswijk Isabelle , Bakhit Mohamed , Stanworth Roger , Hughes David

Background: Adrenocortical carcinoma (ACC) is a rare malignant tumour of the adrenal cortex with an incidence of 0.7-2.0 per million per year. The majority are steroid-producing with non-ACTH dependent hypercortisolism the most frequent biochemical abnormality. Around 10-15% of cases are picked up incidentally on abdominal imaging. Management of ACC during the covid-19 pandemic poses specific challenges. We present the case of a 69-year-old man who was found to have a massive ...

ea0044p170 | Neuroendocrinology and pituitary | SFEBES2016

Audit of adult GH replacement therapy in Derby

Yahia Seifeldin , Quah Edmond , Kinton Rebecca , Ali Hisham , Stanworth Roger

Introduction: In 2003, the UK National Institute for Clinical Excellence (NICE) established guidelines on the use of GH in adults. These guidelines state that recombinant GH should be used only for adults with a severe GH deficiency that severely affects their quality of life. To assess current practice in relation to these guidelines, a review of patients receiving GH treatment was performed. The aims were to assess if adults with GH deficiency met NICE criteria for GH therap...

ea0021p176 | Diabetes and metabolism | SFEBES2009

Testosterone replacement may be beneficial in hypogonadal men with cardiovascular disease

Muraleedharan Vakkat , Dugdale Caroline , Stanworth Roger , Jones Hugh

Hypogonadism is more prevalent in populations with type 2 diabetes (T2D) and/or cardiovascular disease (CVD) and is associated with increase in all-cause and CVD mortality. Testosterone replacement therapy (TRT) improves visceral adiposity, insulin resistance, glycemia, lipids inflammatory cytokines and cardiac ischaemia. The long-term safety of TRT in men with CVD and/or T2D is not known and the British National formulary advises use with caution these groups.<p class="ab...

ea0015p292 | Reproduction | SFEBES2008

Testosterone and the androgen receptor CAG repeat polymorphism are correlated with leptin in men

Stanworth Roger , Kapoor Dheeraj , Channer Kevin , Jones T Hugh

Context: Obesity, diabetes and cardiovascular disease in men are associated with low testosterone levels. Leptin is produced in adipose tissue in proportion to obesity and is known to be negatively associated with testosterone in men. The shared association of testosterone and leptin with obesity is in line with the proposed adipocytokine–hypogonadal–obesity cycle which aims to explain the relationships between these variables.Methods: We inves...

ea0013p161 | Diabetes, metabolism and cardiovascular | SFEBES2007

HDL cholesterol levels are positively associated with testosterone and are lower with shorter androgen receptor CAG repeat lengths in men with Type 2 diabetes

Stanworth Roger , Kapoor Dheeraj , Channer Kevin , Jones T Hugh

Low testosterone levels are a common in men with coronary artery disease and Type 2 diabetes (DM2). Testosterone replacement therapy improves insulin sensitivity and glycaemic control in men with diabetes and improves numerous other cardiovascular risk factors. Interest in testosterone as a potential treatment for cardiovascular disease continues to grow. Low HDL cholesterol (HDL-C) levels are recognised as an independent cardiovascular risk factor and comprise part of the met...

ea0013p258 | Reproduction | SFEBES2007

The androgen receptor CAG repeat polymorphism is associated with serum testosterone levels and obesity in men with Type 2 diabetes

Stanworth Roger , Kapoor Dheeraj , Channer Kevin , Jones T. Hugh

Men with Type 2 diabetes have a high prevalence of low testosterone levels. Testosterone replacement therapy (TRT) has been shown to improve insulin sensitivity and glycaemic control in men with Type 2 diabetes. TRT also reduces fat mass and central obesity. The androgen receptor CAG repeat polymorphism length (AR CAG) correlates positively with transcriptional activity of the receptor as well as body fat, and insulin levels in healthy men. Most studies have not found an assoc...

ea0049ep1192 | Clinical case reports - Thyroid/Others | ECE2017

An adverse outcome in a thyrotoxic lady with propylthiouracil induced necrotising leukocytoclastic vasculitis

Mudenha Emily T , Panthagani Anusha P , Batchelor Jonathan M , Hawari Rand , Stanworth Roger , Hughes David

A 37 year old lady with relapsing Graves’ thyrotoxicosis initially managed on a ‘block and replace regime’ with propylthiouracil and levothyroxine for 7 years had her medication changed to carbimazole after a relapse from non-compliance but developed agranulocytosis. She was then restarted on an increased dose of propylthiouracil alone. Two weeks later, she developed tender purpuric lesions and was admitted after developing painful bullous lesions to her lower l...