Searchable abstracts of presentations at key conferences in endocrinology

ea0019oc36 | Thyroid, reproduction and endocrine tumours | SFEBES2009

Spatio-temporal expression of bone morphogenetic protein (BMP) antagonists during early follicle development

Fenwick M , Franks S , Stark J , Hardy K

BMPs form part of the TGFβ superfamily, which are important regulators of proliferation and differentiation in many cell types. The intraovarian production of specific BMP members and their receptors in a stage-specific manner is crucial for normal follicle development to proceed. Regulation of BMP signalling pathways can occur by intracellular inhibition of the signal transducers (Smads), or by BMP antagonists that bind extracellular BMPs to prevent or alter ligand–...

ea0007p172 | Reproduction | BES2004

The effect of insulin-like growth factor I (IGF-I) on initiation of follicle growth in normal and polycystic ovaries in vitro

Stubbs S , Zachery-Jennings C , Margara R , Trew G , Lavery S , Stark J , Hardy K , Franks S

Early follicular development in polycystic ovaries (PCO) is abnormal; a higher proportion of follicles have entered the growing phase than in normal ovaries [1]. IGF-I stimulates the initiation of preantral follicle growth in a human tissue culture system using a growth factor-reduced extracellular matrix, Matrigel [2]. The aim of this study was to compare the effects of IGF-I on early preantral follicle development in polycystic and normal ovaries. Small ovarian cortical biop...