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ea0035p339 | Developmental Endocrinology | ECE2014

Influence of growth hormone therapeutic supplementation on early hematopoietic stem/progenitor cells in patients with growth hormone deficiency (GHD).

Kawa Milosz , Stecewicz Iwona , Pius-Sadowska Ewa , Paczkowska Edyta , Piecyk Katarzyna , Gawrych Elzbieta , Petriczko Elzbieta , Walczak Mieczyslaw , Machalinski Boguslaw

Objectives: GH plays a crucial role in the regulation of metabolism of human cells. Nevertheless, a direct influence of this hormone on the proliferation, maturation and differentiation of human early hematopoietic stem/progenitor cells (HSPCs) has not been investigated thoroughly. Moreover, certain deviations of hematological parameters, such as anemia or leucopenia, are commonly observed in patients with growth hormone deficiency (GHD) syndrome, which might be substantially ...