Searchable abstracts of presentations at key conferences in endocrinology

ea0073pep11.2 | Presented ePosters 11: Adrenal and Cardiovascular Endocrinology | ECE2021

Establishment of novel multidimensional models for the adrenal gland and adrenal tumors

Shapiro Igor , Peitzsch Mirko , Steenblock Charlotte , Bornstein Stefan , Constanze Hantel

The adrenal gland displays an important role in integrating neuronal, immune, vascular, metabolic and endocrine signals under a common organ capsule. The adrenal is the central organ of the stress response system, responsible for responses to acute and chronic stress stimuli and, thereby, playing a major role in numerous stress-related disorders. While for other diseases translational scientists developed programs to generate healthy cells to regenerate damaged tissues in pati...

ea0086s6.1 | Novel therapeutics and diagnostics in adrenal disease | SFEBES2022

Stem cell therapy in adrenal insufficiency

Steenblock Charlotte , Oikonomakos Ioannis , Malyukov Maria , Bornstein Stefan

Primary adrenal insufficiency is due to impairment of the adrenal gland with ~80% of the cases being due to autoimmune adrenalitis (AddisonÂ’s disease). Other cases of primary adrenal insufficiency might be idiopathic, caused by adrenal metastases, or due to congenital adrenal hyperplasia. Adrenal insufficiency might also be induced by infectious diseases e.g. COVID-19 and, as seen lately in an increasing number of patients, by novel medications targeting hypertension and ...

ea0073oc1.2 | Oral Communications 1: Adrenal and Cardiovascular Endocrinology | ECE2021

YAP/TAZ signaling is involved in the regulation of adrenocortical progenitors in stress

Berger Ilona , Santambrogio Alice , Bornstein Stefan , Andoniadou Cynthia L. , Charlotte Steenblock

A tightly regulated stress system is pivotal for health and the adrenal cortex is a master regulator of the endocrine stress response. The adrenal cortex is characterized by constant cell renewal in part mediated by differentiation and lineage conversion of undifferentiated cell types. To date, the contribution of stem cells to organ plasticity during stress has been implicated but is not fully understood. Recently, we were able to show that a prolonged stress exposure leads t...

ea0081ep55 | Adrenal and Cardiovascular Endocrinology | ECE2022

The asymmetric adrenal in mice and men: Sexual dimorphism and potential hormonal consequences

Bechmann Nicole , Moskopp Mats Leif , Watts Deepika , Steenblock Charlotte , Kanczkowski Waldemar , Wielockx Ben , Bornstein Stefan R , Peitzsch Mirko , Eisenhofer Graeme

Evidence indicates that the adrenals are sexually dimorphic and asymmetric. These differences may have implications for the prevalence and progression of adrenal diseases, which also show asymmetry and sexual dimorphism. The present study aims to characterize the morphological and metabolic differences associated with adrenal sex and asymmetry in mice and humans. Adrenals were compared bilaterally in male and female C57B/6NRj mice with regard to morphological and hormonal char...