Searchable abstracts of presentations at key conferences in endocrinology

ea0090ep1169 | Late Breaking | ECE2023

Distant metastasis in a female patient with thyroid and breast carcinoma with low value of Thyroglobulin. Association between thyroid and breast cancer

Teodoriu Laura , Bilha Stefana , Gafton Elena , Leustean Letitia , Ungureanu Maria-Christina , Preda Cristina , Stefanescu Cipriana

Breast cancer (BC) is the most common type of cancer and the leading cause of cancer-related death in women worldwide. A considerable number of these long-term survivors may therefore have an elevated risk of developing a second primary malignancy (SPM). Thyroid cancer (TC) is the most prevalent endocrine malignancy among women. Epidemiologic studies have indicated that patients with BC have a higher risk of developing TC as an SPM, and vice versa, than would be expected in th...

ea0037ep1318 | Clinical Cases–Thyroid/Other | ECE2015

Is thymectomy a solution for myasthenia gravis associated with autoimmune thyroid diseases?

Vasiliu Ioana , Bodescu Ioana , Stefanescu Cipriana , Ciobanu Delia-Gabriela , Ionescu Lidia , Serban Ionela Lacramioara , Vulpoi Carmen

Myasthenia gravis (MG) and autoimmune thyroid diseases (AITD) may coexist and influence one another clinical expression. The opportunity of thymectomy in this association is controversial, since not all the studies have proven its efficacy. We report eight patients (one man and seven women) diagnosed with AITD (Graves’ disease (GD) – five cases, Hashimoto’s thyroiditis (HT) – three cases) and MG. The AITD diagnosis preceded (two cases), followed (three case...

ea0022p118 | Bone/Calcium | ECE2010

Primary hyperparathyroidism diagnosis – new insights of an old dilemma

Vulpoi Carmen , Stefanescu Cipriana , Ionescu Lidia , Crumpei Felicia , Vasiliu Ioana , Balcan Roxana , Idriceanu Jeanina , Mogos Voichita

Primary hyperparathyroidism (PHPT) is a relatively frequent problem in clinical endocrine practice. Minimally invasive parathyroid surgery is the treatment of choice but requires precise preoperatory localization. The most commonly investigation methods are ultrasonography and scintigraphy, but they are not always diagnostic. PTH assay of the aspirate from an ultrasound-guided fine-needle aspiration (USFNA) may confirm the location of pathological parathyroid tissue. The aim o...

ea0022p428 | Endocrine tumours &amp; neoplasia (<emphasis role="italic">Generously supported by Novartis</emphasis>) | ECE2010

Malignant paraganglioma – the story of a long time survival

Balcan Roxana , Iliescu Dan , Stefanescu Cipriana , Popa Radu , Vasiliu Ioana , Idriceanu Jeanina , Zbranca Eusebie , Vulpoi Carmen

Introduction: Pheochromocytoma and paraganglioma are catecholamine secreting tumours. Malignancy is uncommon (approximately 10% for pheochromocytoma and 20% for paraganglioma) and surgery, when possible, is the first line treatment. However, the prognosis is poor because of frequent local recurrence and/or metastases and the lack of specific chemotherapeutic agents. CASE-REPORT: We present the case of a 60 years-old man who, at the age of 48, was diagnosed with paraganglioma. ...

ea0020p309 | Clinical case reports and clinical reports | ECE2009

A case of giant-cell jaw tumour and primary hyperparathyroidism

Mogos Voichita , Popescu Eugenia , Popa Teodora , Stefanescu Cipriana , Zbranca Eusebie , Grigorovici Alexandru , Mihailovici Sultana , Branisteanu Dumitru

Patient DE, a 49-year-old woman, was operated in 2005 for two giant-cell tumours of the mandible, and in 2008 for another tumour with the same localisation and histology. Inferior cervical ultrasound after the second surgery revealed a parathyroid adenoma of 20×27×15 mm behind the lower pole of the right thyroid lobe, confirmed by Tc tetrofosmin scintigraphy. The patient had metabolic features suggestive for primary hyperparathyroidism: calcium – 10.9 mg/dl (nor...

ea0073ep131 | Endocrine-Related Cancer | ECE2021

Endocrine monitoring after severe hypercalcemia due to primary hyperparathyroidism. In search of lost…MEN 2A?

Teodoriu Laura , Hogea Maximilian , Scripcariu Viorel , Ioan Bianca , Leustean Letitia , Ungureanu Christina , Stefanescu Cipriana , Preda Cristina

The association between primary hyperparathyroidism and pheochromocytoma is present in multiple endocrine neoplasia type 2A (MEN 2A) along with medullary carcinoma or it can be a simple simultaneousness. The presence of the genetic mutation is mandatory in order to have a positive diagnosis of MEN. We report the case of a female patient 63 years old admitted in our department for a large adrenal incidentaloma (10 cm) with no clinical signs of adrenal dysfunction. An adrenal bi...

ea0081ep86 | Adrenal and Cardiovascular Endocrinology | ECE2022

Head and neck paraganglioma: exploring the metastasizing potential. Case report

Teodoriu Laura , Boboc Andreea , Patrascu Ana-Maria , Bilha Stefana , Leustean Letitia , Ungureanu Maria-Christina , Stefanescu Cipriana , Preda Cristina

Introduction: Paragangliomas (PGLs) are tumors originating from neural crest-derived cells situated in the region of the autonomic nervous system ganglia. Head-and-neck PGLs (HNPGLs) originate from the sympathetic and parasympathetic paraganglia, most frequently from the carotid bodies and jugular, tympanic and vagal paraganglia, and are usually non-catecholamine secreting.Case report: We present the case of a 60 years old male patient, which was admitte...

ea0090ep1136 | Late Breaking | ECE2023

Parathyroid carcinoma - case report

Teodoriu Laura , Siriteanu Andreea , Iancu Dragos , Bugean Gema , Danila Radu , Velicescu Cristian , Andriescu Elena-Corina , Ciobanu Delia , Stefanescu Cipriana

Parathyroid carcinoma (PC) is a rare endocrine tumor accounting for 0.5–6% or less in cases of primary hyperparathyroidism. According to The American Joint Committee on Cancer (AJCC) eighth edition, the histopathological criteria for PC include the presence of vascular invasion with capsular invasion and progression and/or metastasis to adjacent tissues. However, the small number of cases of PC makes it difficult to predict prognosis in the postoperative period of PC. We ...

ea0037ep1312 | Clinical Cases–Thyroid/Other | ECE2015

A rare association: primary hyperparathyroidism and thyroid papillary carcinoma: case report

Zmau George-Sebastian , Preda Cristina , Stefanescu Cipriana , Danila Radu , Ciobanu Delia , Crumpei Iulia , Belceanu Alina Daniela , Manolachie Adina , Vulpoi Carmen

Introduction: Although, the relationship between pathological process of the parathyroid and thyroid is common, concurrence of primary hyperparathyroidism (pHPT) and papillary thyroid carcinoma (PTC) is extremely rare, probably because, unlike with medullary thyroid cancer, they have not a common embryologic origin. We present a case with this uncommon association.Case report: A 67-year-old woman with multinodular goitre was addressed in endocrinology fo...

ea0056p149 | Neuroendocrinology | ECE2018

Diagnostic difficulties, management and treatment in neuroendocrine tumors

Nechita Mirela Claudia , Tudurean-Olteanu Anca Georgiana , Hrisca Anamaria , Stefanescu Cipriana , Stolniceanu Cati Raluca , Florescu Alexandru , Ungureanu Maria Christina

Introduction: Diagnosis of NETs (neuroendocrine tumors) is based on clinical manifestations, peptide and amine secretion, specialized radiological and nuclear imaging, secured by detailed histology and immunohistochemistry, which should be obtained whenever possible. Biomarkers are still the mainstay in the diagnosis and follow-up of patients with NETs.Case report: We present the case of a 36-year-old patient with no significant pathological personal his...