Searchable abstracts of presentations at key conferences in endocrinology

ea0014p551 | (1) | ECE2007

Comparison of basal ghrelin and leptin serum levels and after an oral glucose tolerance test in active and inactive acromegalic patients

Roemmler Josefine , Otto Bärbel , Steffin Birgit , Bidlingmaier Martin , Schopohl Jochen

Leptin and ghrelin are correlated to acute and chronic nutritional status. Elevated BMI and fat mass as well as food intake increase leptin levels whereas ghrelin levels are reduced. Ghrelin stimulates growth hormone (GH) secretion. The influence of GH on ghrelin is unclear. Since GH reduces fat mass and is dependent on nutritional status we performed this prospective cross sectional study in order to investigate any interaction between GH, ghrelin and leptin levels in active ...

ea0014p167 | (1) | ECE2007

Predictive value of pituitary histology on clinical outcome in acromegaly: a retrospective cohort study

Steffin Birgit , Saeger Wolfgang , Quabbe Hans-Jürgen , Petersenn Stephan , Ludecke Dieter K , Honegger Jürgen , Buchfelder Michael , Reincke Martin

Immunohistochemistry is commonly performed on tumour specimen obtained during transsphenoidal surgery, but its predictive value for clinical outcome is largely unknown. The aim of this study was to compare clinical and biochemical outcome characteristics after surgery with histological tumour properties. This was achieved by matching data from the German Acromegaly Register with those of the Pituitary Tumour Registry of the German pituitary working group. From 285 out of 1543 ...