Searchable abstracts of presentations at key conferences in endocrinology

ea0084ps1-04-32 | Thyroid Hormone Transporters and Development | ETA2022

Three-dimensional spheroids: a new approach for the identification and characterization of novel markers for tumor-initiating cells subpopulations in thyroid cancer

Ghiandai Viola , Stellaria Grassi Elisa , Fugazzola Laura , Persani Luca

Thyroid cancer (TC) is the most common endocrine malignancy, with an increasing number of diagnosis in the last decades. Of all TC histotypes, the poorly differentiated and anaplastic TCs (PDTC and ATC) have a very poor prognosis because of their invasiveness and metastatic behavior, as well as their insensitivity to radioactive-iodine treatment. In the last years, the stem-cell model has been proposed to further explain TC carcinogenesis. According to this model, only a subse...

ea0084ps2-08-72 | Thyroid Cancer BASIC | ETA2022

The extracellular matrix actively influence thyroid cancer cells sensitivity to TKIS

Stellaria Grassi Elisa , Ghiandai Viola , Fugazzola Laura , Persani Luca

Thyroid cancer (TC) is the most common endocrine tumor and its incidence has increased faster than in any other malignancy. Although TCs are usually well differentiated, disease recurrence or persistence is high, because of local and distant metastasis and therapeutic resistance. As in other cancer types, despite the promising results obtained in pre-clinical studies, the efficacy of Targeted Therapy is highly variable and therapy resistance is not uncommon. This may be due to...

ea0070aep882 | Thyroid | ECE2020

In vitro modeling of thyroid cancer cells and fibroblasts interplay

Stellaria Grassi Elisa , Ghiandai Viola , Pogliaghi Gabriele , Fugazzola Laura , Persani Luca

Thyroid cancer (TC) is the most common endocrine tumor and its incidence has increased faster than in any other malignancy. Although TCs are usually well differentiated, disease recurrence or persistence is high, because of local and distant metastasis and therapeutic resistance. Among the different genetic alterations, BRAFV600E is the most frequent one. Several studies tried to establish a correlation between BRAFV600E and patients outcome, with controversial results. Nevert...

ea0041oc14.1 | Thyroid Cancer | ECE2016

Tumor and normal thyroid stem-like cells: from tissues to zebrafish

Cirello Valentina , Vaira Valentina , Gaudenzi Germano , Stellaria Grassi Elisa , Vitale Giovanni , Ricca Dario , Bosari Silvano , Vicentini Leonardo , Persani Luca , Ferrero Stefano , Fugazzola Laura

Introduction: Cells with stem-like properties have been reported in benign and malignant thyroid diseases, and can be propagated by culturing them as non-adherent spheres.Design: Aim of the present study was to widely characterize the stem-like cells in tumor and normal thyroid tissues and in the corresponding in vitro-cultured thyrospheres, and to investigate in vivo the proangiogenic potential of thyrospheres in a zebrafish model....

ea0084ps2-09-83 | Thyroid Hormone ACTION | ETA2022

FAM83B is involved in thyroid cancer cell differentiation and migration

Cirello Valentina , Stellaria Grassi Elisa , Pogliaghi Gabriele , Ghiandai Viola , Ermellino Laura , Muzza Marina , Gazzano Giacomo , Persani Luca , Colombo Carla , Fugazzola Laura

FAM83B has been recently identified as an oncogene involved in the development and progression of several malignancies, but its role in thyroid cancers (TC) is still unclear. In the present study, we examined the expression of FAM83B and its possible involvement in cell migration and differentiation, in neoplastic and normal thyroid tissues and in TC human cell lines. We found that FAM83B expression in TC varies according to tumor histotype, being si...