Searchable abstracts of presentations at key conferences in endocrinology

ea0041gp33 | Bone & Calcium Homeostasis | ECE2016

Relationships between lower-limb muscle strength and tibial outcomes in ageing UK men

Zengin Ayse , Pye Stephen R , Cook Michael J , Adams Judith E , Wu Frederick C W , O'Neill Terence W , Ward Kate A

Ageing is associated with sarcopenia, osteoporosis and an increased risk of falling, which together contribute to increased fracture risk. There are few data describing the associations between functional measures of muscle and bone during ageing. Therefore, the aim of this study was to examine in ageing men associations between measures of lower-limb muscle strength and age and then to investigate the relationships with tibial bone outcomes.Men (n</...

ea0037oc2.4 | Reproduction | ECE2015

Low free testosterone is associated with hypogonadal symptoms in men with normal total testosterone levels: results from the European Male Ageing Study

Antonio Leen , Wu Frederic , O'Neill Terrence , Pye Stephen , Carter Emma , Finn Joseph , Laurent Michael , Huhtaniemi Ilpo , Rutter Martin , Rastrelli Giulia , Forti Gianni , Bartfai Gyorgy , Casanueva Felipe , Kula Krzysztof , Punab Margus , Giwercman Aleksander , Claessens Frank , Decallonne Brigitte , Vanderschueren Dirk

Background: During ageing, total testosterone (TT) declines and SHBG increases, resulting in a greater decline of free testosterone (FT) compared to TT. However, guidelines suggest using TT to diagnose androgen deficiency and to reserve FT only for men with borderline TT. We investigated if isolated low FT or isolated low TT was associated with androgen-related endpoints in healthy men.Methods: 3369 community-dwelling men, aged 40–79, were included....

ea0070aep184 | Bone and Calcium | ECE2020

Free 25-hydroxyvitamin D, but not free 1.25-dihydroxyvitamin D, predicts all-cause mortality in ageing men

Antonio Leen , Dejaeger Marian , Bouillon Roger , Wu Frederick , O’Neill Terence , Pye Stephen , Huhtaniemi Ilpo , Rastrelli Giulia , Forti Gianni , Casanueva Felipe , Slowikowska-Hilczer Jolanta , Punab Margus , Tournoy Jos , Vanderschueren Dirk

Background: Total 25 hydroxyvitamin D (25(OH)D) and total 1.25 dihydroxyvitamin D (1.25(OH)2D) are associated with all-cause mortality. The free hormone hypothesis postulates that only the free vitamin D fraction can exert its biological function. Recently some studies suggested that free 25(OH)D levels might be a better predictor for clinical outcomes, including mortality.Objective: To study the association between total and free 25(OH)D and ...

ea0071006 | Sexual symptoms predict all-cause mortality independently of sex steroids in ageing men | BES2020

Sexual symptoms predict all-cause mortality independently of sex steroids in ageing men

Leen Antonio , Marian Dejaeger , CW Wu Frederick , WO'Neil Terence , R Pye Stephen , T Huhtaniemi Ilpo , Giulia Rastrelli , Gianni Forti , F Casanueva Felipe , Jolanta Slowikowska-Hilczer , Margus Punab , Dirk Vanderschueren , Jos Tournoy , the EMAS Study Group

Background: The association between low testosterone (T) and higher mortality in men remains controversial. Most studies focus only on the association between total T (TT) and mortality. While TT declines with age, free T (FT) shows a greater fall, due to the rise in SHBG. Moreover, also sexual dysfunction, often co-existing with low T, has been associated with mortality in ageing men.Objective: To study the interrelationships between ...

ea0037gp.08.01 | Reproduction: Male and endocrine disruptors | ECE2015

Characteristics and predictors of primary hypogonadism in ageing men: longitudinal data from the European Male Ageing Study

Ahern Tomas B , Huhtaniemi Ilpo T , Carter Emma L , Finn Joseph D , Pye Stephen R , O'Neill Terence W , Bartfai Gyorgy , Casanueva Felipe F , Forti Gianni , Giwercman Aleksander , Han Thang S , Kula Krzysztof , Lean Michael EJ , Pendleton Neil , Punab Margus , Vanderschueren Dirk , Wu Frederick C W

Introduction: Primary hypogonadism (PHG, testosterone <10.5 nmol/l and LH >9.5 U/l) without a recognisable cause affects ~2% of community-dwelling middle-aged and older men. We sought to identify the clinical significance of, and risk factors for, this apparently age-related hypogonadal state.Methods/design: The European Male Ageing Study (EMAS) is a prospective observational cohort survey of 3.369 community-dwelling men aged 40–79 in eight ...