Searchable abstracts of presentations at key conferences in endocrinology

ea0099p521 | Pituitary and Neuroendocrinology | ECE2024

Assessing long-term safety and efficacy of osilodrostat in prior- and new-use patients with endogenous cushing’s syndrome: a 1-year real-world interim analysis of the non-interventional, multinational LINC 6 study

Castinetti Frederic , Geer Eliza , Biller Beverly , Feelders Richard , Fleseriu Maria , Pivonello Rosario , Reincke Martin , Tabarin Antoine , Le Mouhaer Jeannie , Stermenska Julia , Maldonado Mario , Bancos Irina

Introduction: Potent 11β-hydroxylase inhibitor osilodrostat provides cortisol level control in patients with Cushing’s syndrome (CS), as demonstrated by the LINC clinical development programme in Cushing’s disease (CD) patients.1 We report data from year 1 of the prospective observational LINC6 study (NCT05382156), evaluating long-term safety and efficacy of osilodrostat in CS patients during 3 years of routine clinical practice.<p class="abstext"...

ea0099ep270 | Pituitary and Neuroendocrinology | ECE2024

Long-term safety and efficacy of subcutaneous pasireotide in patients with cushing’s disease: results from a non-interventional study

Bogazzi Fausto , Cannavo Salvatore , Giordano Carla , Detomas Mario , Scaroni Carla , Raverot Gerald , Schopohl Jochen , Georgescu Carmen , Piacentini Andrea , Mueller Arnd , Stermenska Julia , Bertherat Jerome

Introduction: Subcutaneous (sc) pasireotide effectively reduces cortisol levels and is generally well tolerated in Cushing’s disease (CD) patients, as demonstrated by a Phase III study (NCT00434148). We report data from a non-interventional, multinational study (NCT02310269) evaluating long-term safety and efficacy of pasireotide sc for CD patients.Methods: Adults with CD, for whom surgery has failed or is not an option, were analysed by time of pas...