Searchable abstracts of presentations at key conferences in endocrinology

ea0032p886 | Pituitary – Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2013

Short-term exercise-induced GH response in athletes: differential results for runners and bikers when tested on bicycle

Zueger Thomas , Bucher Julie , Christ Emanuel , Stettler Christoph

Background/introduction: SUB:Pituitary – Clinical (Generously supported by IPSEN)We have previously shown that GH assessment during a standardized aerobic exercise of moderate intensity is a reliable test with high diagnostic accuracy in predicting severe GH deficiency (GHD) in adult individuals. However, these studies comprised comparably long exercise durations around 60 min or longer. To improve clinical applicability of exercise testing in the diagnosis of GH...

ea0022p290 | Diabetes | ECE2010

Response of interleukin-6 during euglycaemic and hyperglycaemic exercise in patients with type 1 diabetes mellitus

Jenni Stefan , Wueest Stephan , Konrad Daniel , Stettler Christoph

Background: Secretion of IL-6 during exercise is hypothesised to be regulated according to substrate availability within the working muscle. We have previously shown that energy supply in type 1 diabetes during aerobic exercise in hyperglycaemia strongly relies on carbohydrate oxidation whereas a physiological shift from carbohydrate to lipid oxidation occurs in euglycaemia. The present study investigated whether IL-6 response to exercise is different in euglycaemia compared w...

ea0014p32 | (1) | ECE2007

Effects of rosiglitazone (RGZ) and pioglitazone (PGZ) on serum androgens and urinary steroid profile in patients with type 2 diabetes: A prospective, randomised cross-over study

Chappuis Bernard , Braun Monika , Stettler Christoph , Diem Peter , Christ Emanuel

Background: Glitazones (GZ) influence androgen biosynthesis in PCO syndrome. At present it is unknown whether a) steroid hormone metabolism is influenced by GZ in patients with type 2 diabetes b) there is a differential effect of RGZ and PGZ on steroid hormone metabolism c) this effect is sex-specific and d) this effect is mediated by changes in insulin sensitivity. Therefore, urinary steroid profiles and serum total testosterone and DHEA levels were analysed before and after ...

ea0049ep1090 | Clinical case reports - Thyroid/Others | ECE2017

A rare cause of a 46, XY disorder of sex development diagnosed in an adult patient

Feller Katrin , Fluck Christa , Audi Laura , Fernandez-Cancio Monica , Stettler Christoph

The defective conversion of testosterone to dihydrotestosterone due to a steroid 5-alpha-reductase 2 deficiency results in a unique form of 46, XY disorder of sexual development (DSD). Dihydrotestosterone is essential for the embryonic differentiation of the external male genitalia and the prostate. Steroid 5-alpha-reductase 2 deficiency is an autosomal recessive disorder in which genetic males have a predominantly female phenotype with female external genitalia but male inter...

ea0035p200 | Cardiovascular Endocrinology &amp; Lipid Metabolism | ECE2014

Flexibility of ectopic lipids in physically active, healthy individuals

Bucher Julie , Krusi Marion , Kreis Roland , Zuger Thomas , Ith Michael , Stettler Christoph , Boesch Chris

Introduction: Ectopic lipids are fuel stores in non-adipose tissues (i.e. skeletal muscle (IMCL), liver (IHCL), heart (ICCL)). An aerobic-exercise bout leads to a decrease in IMCL (‘working tissues’), whereas it is not established whether a single but of exercise influences IHCL or ICCL.Increased IMCL and IHCL have been related to impaired insulin action in skeletal muscle and liver. It is hypothesized that fat availability (subcutaneous and vi...

ea0032p180 | Cardiovascular Endocrinology &amp; Lipid Metabolism | ECE2013

The effect of aerobic exercise on ectopic lipids intramyocellular, intrahepatocellular, and intracardiomyocellular lipids in physically active, healthy individuals

Kruesi Marion , Bucher Julie , Kreis Roland , Ith Michael , Zueger Thomas , Stettler Christoph , Boesch Chris , Christ Emanuel

Introduction: Ectopic lipids are fuel stores in non-adipose tissues (i.e. skeletal muscle (IMCL), liver (IHCL), and heart (ICCL)). It is recognized that IMCL can be depleted by physical activity and repleted by dietary fat intake indicating metabolic flexibility. In contrast, preliminary data suggested that aerobic exercise increases IHCL. Data on the acute effect of aerobic exercise on ICCL is scarce.Increased IMCL and IHCL have consistently been relate...

ea0022p306 | Diabetes | ECE2010

Exercise-related levels of acetylcarnitine in skeletal muscle of individuals with type 1 diabetes in Eu- and hyperglycaemia assessed by 1H-MR spectroscopy

Jenni Stefan , Boss Andreas , Kreis Roland , Ith Michael , Christ Emanuel , Boesch Chris , Stettler Christoph

Background: Acetylcarnitine (AC) is involved in intramyocellular fuel metabolism during exercise. So far, little is known on exercise-associated myocellular AC levels in patients with type 1 diabetes. In particular, it is unknown whether AC levels differ according to glucose values in diabetic patients. 1H magnetic resonance spectroscopy (MRS) of the skeletal muscle allows for the non-invasive assessment of acetylcarnitine (AC) accumulation. The present study assess...

ea0020p568 | Neuroendocrinology, Pituitary and Behaviour | ECE2009

Long-term follow-up of female patients with prolactinoma: is there a place for surgery in the therapy of prolactinoma?

Frey Janine , Krull Ina , Sahli Rahel , Stettler Christoph , Fischli Stefan , Diem Peter , Christ Emanuel

Background: Medical therapy with dopamine agonists (DA) is the primary treatment in most patients with prolactinomas. ‘Classical’ surgical indications are mainly intolerance of DA therapy or non-responders. Focusing on a possible shift of recent indications towards a surgical approach, we retrospectively analyzed the long-term results of surgical treatment and compared them to the medically treated female patients with prolactinomas.Patients an...

ea0020p569 | Neuroendocrinology, Pituitary and Behaviour | ECE2009

Clinical presentation, long-term follow-up and bone morbidity of male patients with prolactinoma

Frey Janine , Krull Ina , Sahli Rahel , Stettler Christoph , Fischli Stefan , Diem Peter , Christ Emanuel

Background: In contrast to females with prolactinoma, male patients usually present with a history of long-standing hypogonadism and a macroadenoma on MRI-scan. Data is scarce about the effect of hypogonadism on bone health in these patients. We, therefore, investigated retrospectively the cohort of male patients with prolactinoma at our institution.Patients and methods: Between 1983 and 2007, the chards of 44 male patients with prolactinoma were reviewe...

ea0014p104 | (1) | ECE2007

Bone density in patients with non-functioning pituitary adenomas (NFA)

Fischli Stefan , Stettler Christoph , Sahli Rahel , Schwab Silvia , Chappuis Bernard , Jenni Stefan , Diem Peter , Christ Emanuel

Background: Surgically treated patients with NFA often present with secondary hypogonadism. Hypogonadism is a well known risk factor for osteopenia or osteoporosis. The aim of this study was to assess (a) the frequency of osteopenia/osteoporosis in a single centre Swiss cohort of patients with operated NFA and (b) whether gender or hypogonadism impacts on bone density at follow up.Methods: Data of patients with NFAs diagnosed between 1967 and 2005 were a...