Searchable abstracts of presentations at key conferences in endocrinology

ea0071028 | Fertility in men with 5-alpha reductase deficiency | BES2020

Fertility in men with 5-alpha reductase deficiency

Wout Devlies , Elisabet Van Loon , Steven Joniau , Frank Claessens , Leen Antonio , Dirk Vanderschueren

Introduction: 5 Alpha reductase deficiency (5-ARD) is a rare autosomal recessive disorder causing disturbance of sex development. 5 Alpha reductase is an enzyme involved in steroid metabolism, catalyzing testosterone into dihydrotestosterone (DHT), its potent form. 5-ARD therefore results in lower DHT and higher testosterone values. DHT is crucial for the differentiation of the urogenital sinus and genital tubercle into the external genitalia, urethra and prostate, while the v...

ea0042p10 | (1) | Androgens2016

Metastases-prone localized prostate cancer: a genomic analysis

Van den Broeck Thomas , Gevaert Thomas , Prekovic Stefan , Boeckx Bram , Smeets Elien , Ong Kaye , Lehrer Jonathan , Haddad Zaid , Erho Nicholas , Helsen Christine , Lambrechts Diether , Buerki Christine , Davicioni Elai , Joniau Steven , Claessens Frank

Clinical features of the primary prostate tumor remain insufficient for clinicians to accurately define patients at highest risk of developing metastases. However, the primary tumor is the source of these metastases, and thus should contain information on its metastatic potential. We hypothesized that the combination of a primary tumor’s copy number alterations (CNAs) and genome-wide transcriptome information would give us more insight in the biology of metastases-prone l...