Searchable abstracts of presentations at key conferences in endocrinology

ea0038p185 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2015

Transcriptome profiles of human pancreatic islets following transient ischemia identify inflammatory and cell death responses

Kelly Amy , Smith Kate , McCarthy Fiona , Smith Breonna , Badarinarayana Vasudeo , Steyn Leah , Strop Peter , Limesand Sean , Papas Klearchos

Islet transplantation, an effective treatment for Type I Diabetes, is compromised by transient ischemia. Ischemia reduces the viability and function of transplanted islets and may also promote signals that lower islet efficacy. In order to characterize the response of human islets to transient ischemia, high-throughput sequencing was employed to determine global gene expression. Islets isolated from healthy donors (n=4) were either pelleted in microcentrifuge tubes (i...