Searchable abstracts of presentations at key conferences in endocrinology

ea0077pl2 | Society for Endocrinology Starling Medal Lecture | SFEBES2021

Strategies to turn up the heat – investigating human brown adipose tissue function

Stimson Roland

The obesity epidemic has underlined the need for new treatments to aid weight loss and prevent the associated sequelae of obesity such as type 2 diabetes, hypertension, dyslipidaemia and cardiovascular disease. The relatively recent discovery of brown adipose tissue (BAT) in adult humans has revived interest in activating this tissue to increase energy expenditure as a novel treatment for obesity and associated metabolic disease. BAT is a thermogenic organ that generates heat ...

ea0081ap1 | The European Journal of Endocrinology Award Lecture | ECE2022

The regulation of human brown adipose tissue

Stimson Roland

The obesity epidemic has underlined the need for new treatments to aid weight loss and prevent the associated cardiometabolic sequelae of obesity. The relatively recent discovery of brown adipose tissue (BAT) in adult humans has revived interest in activating this tissue to increase energy expenditure as a novel treatment for these conditions. BAT is a thermogenic organ that generates heat to maintain body temperature in a cold environment. While BAT mass and activity are redu...

ea0044fut2.1 | Futures 2: Mapping your route through the Research Funding maze | SFEBES2016

Starter grants and building your pilot data

Stimson Roland

Obtaining research independence and running your own research group can seem very far away at the end of your PhD and during your early postdoctoral career. However, starter grants are an invaluable resource to help you down this path, allowing you to develop and strengthen your research career, pursue independent strands of research, improve your ability to write grants and make you more competitive to obtain more substantial funding.Starter grants are ...

ea0044ep15 | (1) | SFEBES2016

Primary pigmented nodular adrenocortical disease: a rare cause of Cushing’s syndrome

Kyle Catriona , Stimson Roland

A 34-year-old lady presented with a 3 year history of central weight gain, hypertension and secondary amenorrhoea. Initial 24-hour urinary free cortisol (UFC) was raised (536 nmol/24 hr) and subsequent overnight dexamethasone suppression test (DST) was elevated at 593 nmol/L. Low and high dose DST confirmed the diagnosis of Cushing’s syndrome with a slightly unusual trend of increasing cortisol levels compared with baseline. ACTH levels were undetectable while adrenal ima...

ea0015oc3 | Young Endocrinologist prize session | SFEBES2008

Does 11βHSD1 in visceral adipose tissue (VAT) deliver cortisol to the liver? Studies with portal vein sampling and tracer infusion in humans

Stimson Roland , Andrew Ruth , Redhead Doris , Hayes Peter , Walker Brian

Cortisol is regenerated from cortisone by 11βHSD1 reductase in cells from VAT. Mice overexpressing 11βHSD1 in adipocytes have more glucocorticoids in the portal vein (PV) and hepatic insulin resistance. In humans, hepatic vein (HV) sampling during D4-cortisol tracer infusion confirmed substantial splanchnic cortisol generation, and indirect modelling suggested major contributions from both liver and VAT. PV sampling in dogs, however, did not reveal cortisol release f...

ea0013p282 | Steroids | SFEBES2007

Acute improvement in insulin sensitivity by PPARgamma-agonists is not mediated by inhibition of glucocorticoid action in humans

Stimson Roland , Wake Deborah , Andrew Ruth , Walker Brian

PPARgamma-agonists improve insulin sensitivity and discourage visceral fat accumulation but mechanisms remain uncertain. In rodents, PPARgamma-agonists downregulate 11beta-hydroxysteroid dehydrogenase type 1 (11b-HSD1) in adipose tissue (AT), thereby potentially decreasing intra-adipose glucocorticoid (GC) concentrations. We tested whether PPARgamma-agonists regulate 11b-HSD1 in humans, and if their insulin-sensitising effect is GC-dependent.12 healthy m...

ea0077p185 | Metabolism, Obesity and Diabetes | SFEBES2021

Measurements of skin temperature in lean and obese humans at thermoneutrality and following cold exposure

Choong Kwok T’ng , Ramage Lynne E , Kelman Alexandra , Semple Robert K , Stimson Roland H

Background: Infrared thermography (IRT) can assess human brown adipose tissue (BAT) activity non-invasively. However, it remains unclear if skin temperature is altered in obesity. We compared skin temperatures of lean and obese individuals following cold exposure and studied its relationship with energy expenditure (EE).Methods: 10 lean (age 28.3±2.1y, BMI 21.5±0.4kg/m2) and 10 obese (age 28.2±2.1y, BMI 36.2±1.3kg/m2</...

ea0077lb12 | Late Breaking | SFEBES2021

Hypoxia re-programmes adipocyte metabolism to drive cancer cell proliferation

Aird Rhona , Wills Jimi , Roby Katherine , Stimson Roland , Finch Andy , Michailidou Zoi

Obesity increases the risk of certain cancers, especially tumours that reside close to adipose tissue (e.g. breast cancers and ovarian metastasis to omentum). Adipose tissue in obesity and tumour micro-environmentsshare a common pathogenic feature, oxygen deprivation (hypoxia, Hx). Here we hypothesised that this hypoxic microenvironment causes changes in key metabolic pathways in adipocytes leading to increased cancer cell growth. To test this, human or mouse breast (BC) and o...

ea0086p205 | Metabolism, Obesity and Diabetes | SFEBES2022

UCP1 expression in human brown adipose tissue is inversely associated with cardiometabolic risk factors

Choong Kwok T'ng , E Ramage Lynne , Kelman Alexandra , Wakelin Sonia J , Stimson Roland H

Introduction: Brown adipose tissue (BAT) increases energy expenditure and is a potential therapeutic target for obesity and associated cardiometabolic disease. It is unclear whether human BAT activity is reduced in obesity, as BAT 18F-fluorodeoxyglucose uptake is reduced but BAT metabolic activity measured using11C-acetate PET is preserved. BAT thermogenesis relies on the presence of uncoupling protein 1 (UCP1), which uncouples oxidative phosphorylation f...

ea0044p24 | Adrenal and Steroids | SFEBES2016

Tissue-specific regulation of recycling between cortisol and cortisone by insulin and obesity

Anderson Anna , Andrew Ruth , Homer Natalie , Hughes Kate , Karpe Fredrik , Stimson Roland , Walker Brian

Intracellular cortisol is regulated by 11βHSD1. Although the field has focused on regeneration of cortisol from inert cortisone by 11β-reductase activity of 11βHSD1, we have used stable isotope tracers and arteriovenous sampling to quantify simultaneous dehydrogenase (cortisone generation) and reductase (cortisol regeneration) in human adipose and skeletal muscle. In vitro studies suggest insulin regulates this balance of reductase vs dehydrogenase acti...