Searchable abstracts of presentations at key conferences in endocrinology

ea0063gp157 | Cushing's | ECE2019

DNA Methylation and fMRI responses in patients with Cushing’s syndrome in remission – suggestions of a functional link between hypercortisolism and neurocognitive dysfunction

Glad Camilla , Andersson-Assarsson Johanna , Stomby Andreas , Dahlqvist Per , Nyberg Lars , Bergthorsdottir Ragnhildur , Johannsson Gudmundur , Ragnarsson Oskar

Introduction: Compared with healthy controls, women with CushingÂ’s syndrome (CS) in long-term remission have reduced functional brain responses during episodic and working memory testing and decreased overall levels of DNA methylation in blood cells. Here, we sought to test the hypothesis that functional brain responses in the prefrontal cortex and hippocampus are related to epigenetic changes in subjects with CS in long-term remission.Methods: In t...