Searchable abstracts of presentations at key conferences in endocrinology

ea0011p368 | Diabetes, metabolism and cardiovascular | ECE2006

Estrogen receptor alpha (ER ‘alpha’) gene polymorphisms and first-ever primary intracerebral hemorrhage (PICH)

Strand M , Söderström I , Wiklund P-G , Hallmans G , Weinehall L , Söderberg S , Olsson T

Context: Estrogens may have protective properties in the cardiovascular system, linked to the activation of estrogen receptor alpha (ERα), present in vascular smooth muscle cells (VSMCs) and endothelial cells (ECs). ERα-mediated signaling regulates vasodilatation and atherogenesis, and since hypertension and atherosclerosis are major mechanisms in stroke development, we hypothesized that genetic variations in the ERα gene (ESR1) were associated with strok...