Searchable abstracts of presentations at key conferences in endocrinology

ea0051oc5.4 | Oral Communications 5 | BSPED2017

Characterisation of skeletal developmental in mouse models of Duchenne Muscular Dystrophy

Wood Claire , Wong Jarod , Straub Volker , Ahmed Faisal , Farquharson Colin

Short stature and osteoporosis are common in DMD. Glucocorticoids slow disease progression but are associated with further growth retardation and skeletal fragility. The muscular dystrophy x-linked (mdx) mouse is the most commonly used animal model of DMD. However, the phenotype is relatively mild and few medications that have shown therapeutic benefit in the mdx have translated clinically. The utrophin heterozygous mdx mice might be more appropriate...

ea0078p40 | Miscellaneous | BSPED2021

Can playing a computer game assess muscle function? Using ability captured through interactive video evaluation (ACTIVE) in duchenne muscular dystrophy

McElvaney Joseph , Wood Claire , Hollingsworth Kieren G , Hughes Eric , Muni Lofra Robert , Mayhew Anna , Sodhi Jassi , James Meredith , Cheetham Tim , Straub Volker

Introduction: Duchenne muscular dystrophy (DMD) is associated with progressive decline in muscle function and loss of ambulation in the teenage years. Objective assessments of upper limb performance are required but functional assessments and magnetic resonance imaging (MRI) are time consuming and costly. ACTIVE-seated (Ability Captured Through Interactive Video Evaluation) is a fun, inexpensive, movement tracking video game that can measure Functional Reaching Volume (FRV). <...