Searchable abstracts of presentations at key conferences in endocrinology

ea0013p230 | Neuroendocrinology and behaviour (including pituitary) | SFEBES2007

The AVP precursor, Copeptin, predicts the severity of acute and prolonged traumatic brain injury (TBI)

Kleindienst Andrea , Weigel Daniel , Morgenthaler Nils , Struck Joachim , Buchfelder Michael , Brabant Georg

Introduction: The incidence of water and electrolyte disturbances following traumatic brain injury (TBI) is considerable and has been attributed to a dysregulation of the hypothalamic peptide arginine-vasopressin (AVP). Copeptin, the C-terminal part of the AVP prohormone, is stoichiometrically secreted together with mature AVP. Due to his long ex vivo stability, the AVP precursor, copeptin, can be used as a surrogate of AVP readily to be measured in serum or plasma. In ...

ea0016oc1.9 | Neuroendocrinology and pituitary | ECE2008

Oxytocin alleviates the neuroendocrine and cytokine response to bacterial endotoxin in healthy men

Vila Greisa , Clodi Martin , Geyeregger Rene , Riedl Michaela , Stulnig Thomas M , Struck Joachim , Luger Thomas A , Luger Anton

Oxytocin is a hormone and neurotransmitter with antiinflammatory and neuroimmune-modulatory properties. Physiological states of elevated plasma oxytocin levels are associated with reduced hypothalamic┬ľpituitaty┬ľadrenal response to different stressors. We examined the effect of exogenous oxytocin administration on bacterial endotoxin induced innate immune responses in humans. Ten healthy men received in a randomized, placebo-controlled, cross-over design (1) placebo, ...

ea0041oc12.3 | Obesity | ECE2016

Effects of weight loss and long-term weight maintenance with diets varying in protein and glycemic index on circulating pro-neurotensin in the Diet, Obesity, and Genes (DiOGenes) Study: a randomized, controlled trial

Rudovich Natalia , Bernigau Wolfgang , Pivovarova Olga , Osterhoff Martin , Sparwasser Andrea , Bergmann Andreas , Struck Joachim , van Baak Marleen A , Jebb Susan A , Papadaki Angeliki , Alfredo Martinez J , Handjieva-Darlenska Teodora , Kunesova Marie , Hager Jorg , Valsesia Armand , Viguerie Nathalie , Langin Dominique , Astrup Arne , Saris Wim H M , Pfeiffer Andreas F H

Aims: Elevated levels of neurotensin (NT), a neurotransmitter and postprandial secreted intestinal hormone, are associated with an increased risk of diabetes, cardiovascular disease and breast cancer. Here we studied the regulation of circulating pro-NT (a stable NT precursor fragment) by weight loss and dietary interventions.Methods: DiOGenes is a pan-European controlled dietary intervention study in overweight adults who first lost body weight on an 8-...