Searchable abstracts of presentations at key conferences in endocrinology

ea0022p717 | Obesity | ECE2010

Characterisation of serum and glucocorticoid-induced kinase 1 in adipose tissue

Vila Greisa , Kiefer Florian , Reiter Marie Helene , Zeyda Maximilian , Stulnig Thomas M , Luger Anton

Serum and glucocorticoid-induced kinase 1 (Sgk1) is an early transcriptional target of glucocorticoids with antiapoptotic effects. Sgk1 becomes active after phosphorylation by growth factors such as insulin and IGF1 through the PI3 kinase/PDK1 pathway. Activated Sgk1 increases the cellular uptake of glucose by increasing the membrane abundance of glucose transporters GLUT1 and GLUT4. Here we present data on the expression and regulation of Sgk1 in adipose tissue using three di...

ea0016oc1.9 | Neuroendocrinology and pituitary | ECE2008

Oxytocin alleviates the neuroendocrine and cytokine response to bacterial endotoxin in healthy men

Vila Greisa , Clodi Martin , Geyeregger Rene , Riedl Michaela , Stulnig Thomas M , Struck Joachim , Luger Thomas A , Luger Anton

Oxytocin is a hormone and neurotransmitter with antiinflammatory and neuroimmune-modulatory properties. Physiological states of elevated plasma oxytocin levels are associated with reduced hypothalamic┬ľpituitaty┬ľadrenal response to different stressors. We examined the effect of exogenous oxytocin administration on bacterial endotoxin induced innate immune responses in humans. Ten healthy men received in a randomized, placebo-controlled, cross-over design (1) placebo, ...