Searchable abstracts of presentations at key conferences in endocrinology

ea0014p190 | (1) | ECE2007

Closure by iptakalim, a cardiovascular K(ATP) channel opener, of rat islet beta-cell K(ATP) channels and its molecular basis

Suga Sechiko , Wakui Makoto , Kudo Takanori , Ogawa Yoshiji

Diabetes mellitus is a group of diseases characterized by high levels of blood glucose resulting from defects in insulin production, insulin action, or both. Diabetes patients usually have accompanying cardiovascular disorders. Sulfonylureas have been the leading oral antihyperglycemic agents for type 2 diabetes treatment, which currently still constitute the most popular anti-diabetic drugs. Nevertheless, concern has arisen over the side effects of sulfonylureas on the cardio...

ea0014p28 | (1) | ECE2007

Novel mechanism of chronic exposure of oleic acid-induced insulin release impairment in rat pancreatic β-cells

Kudo Takanori , Ogawa Yoshiji , Suga Sechiko , Tomotsune Ken , Hasegawa Noriyuki , Suda Toshihiro , Wakui Makoto

A sustained, high circulating level of free fatty acids (FFAs) is an important risk factor for the development of insulin resistance, islet beta-cell dysfunction, and pathogenesis of type 2 diabetes. Here, we report a novel mechanism of chronic exposure of oleic acid (OA)-induced rat insulin release impairment. Following a 4-day exposure to 0.1 mM OA, there was no significant difference in basal insulin release when comparing OA-treated and untreated islets in the presence of ...