Endocrine Abstracts

Cerebro-spinal fluid (CSF) rhinorrhea is a recognised complication of pituitary surgery, and occasionally occurs following pituitary radiotherapy. Macroprolactinomas (MPRL) may result in spontaneous or dopamine-agonist-induced CSF leaks, however no detailed large comparisons have been made with non-functioning adenomas (NFA). The incidence of this phenomenon and the mechanisms underlying it are not understood.We have performed a retrospective review of s...

Objective: Macroprolactinomas (MPRL) may result in spontaneous or dopamine-agonist-induced CSF rhinorrhoea. The incidence of, and mechanisms underlying this phenomenon are poorly understood. In this study, we aimed to determine the incidence of non-surgical (spontaneous and dopamine-agonist-induced) rhinorrhoea, and to identify biochemical, radiological and histopathological factors associated with this phenomenon.Methods: We retrospectively reviewed MPR...

Late onset Cushing’s disease, occurring years following the diagnosis of a silent corticotroph adenoma (SCA) is rare, with very few previously reported cases. We present a series of 5 subjects with SCA, aggressive tumour recurrences and late onset Cushing’s disease.The mean age of subjects at initial presentation was 41 yrs (35–52), sex 3:2 (M:F). There were no clinical features of hypercortisolism at diagnosis. Two subjects had hypocortis...