Endocrine Abstracts

Wnt proteins are morphogens that are involved in morphogenesis, differentiation and stem cell biology in a variety of tissues. In the adrenal cortex, WNT4 is expressed at a higher level in the zona glomerulosa (ZG) and mice deficient in WNT4 have a defect in this zone. In this laboratory we confirmed that WNT4 is expressed at a higher level in the human ZG and showed that this is accompanied by higher expression of a potential antagonist, dickkopf-3 (DKK3). To investigate the ...

Introduction: In everyday practice, doctors often have to deal with patients who show features of depression - it has been proven that in 20–30% of cases it may be related to the ocurrence of another disease, such as hypothyroidism.Aim of study: The aim of the study was to verify the frequency of occurrence features of depression (based on Beck’s scale) in the population of patients with hypothyroidism and comparison to the general population.<...