Searchable abstracts of presentations at key conferences in endocrinology

ea0015p327 | Steroids | SFEBES2008

A paracrine role for 11β-hydroxysteroid dehydrogenase type 1 and glucocorticoids in the murine pancreatic islet

Swali Angelina , Tomlinson Jeremy , Walker Elizabeth , Stewart Paul

Type 2 diabetes manifests when pancreatic β-cells secrete inadequate insulin in response to elevated glucose. A known culprit in metabolic diseases is excessive exposure to glucocorticoids (GCs). GCs increase hepatic gluconeogenesis, decrease insulin sensitivity in skeletal muscle and adipose tissue and suppress the development of β-cells. In rodents, inactive GC 11-dehydrocorticosterone (A) is converted to active corticosterone (B) by the enzyme 11β-hydroxyster...