Searchable abstracts of presentations at key conferences in endocrinology

ea0035p560 | Endocrine tumours and neoplasia | ECE2014

Expression of FSH hormone receptors in pituitary adenomas: a marker of tumour aggressiveness?

Pawlikowski Marek , Kunert-Radek Jolanta , Jaranowska Maria , Radek Maciej , Swietoslawski Jacek , Winczyk Katarzyna

Background: In our earlier study we found that pituitary adenomas, like other human tumours, express ectopically follicle stimulating hormone receptors FSH in intratumoral blood vessels endothelia and/or tumoral cells. The aim of the present paper is to provide the more detailed data on FSHR expression in different subtypes of pituitary adenomas and to evaluate its possible role as a prognostic and/or predictive biomarker in these tumours.Material and me...

ea0035p565 | Endocrine tumours and neoplasia | ECE2014

Effect of thiazolidinediones: PPARγ agonists on hormones secretion by cells of human adrenocortical cancer in vitro

Fuss-Chmielewska Julita , Lawnicka Hanna , Swietoslawski Jacek , Beda-Maluga Karolina , Winczyk Katarzyna

Introduction: Adrenocortical carcinoma (ACC) is characterized by the high malignancy of the lesion, poor prognosis and high mortality rate. The surgical treatment and available chemotherapy have generally low efficacy so the search for new therapeutic options is still necessary. Some research indicated that thiazolidinediones (TZDs)–synthetic ligands of peroxisome proliferator-activated receptor γ (PPARγ) have oncostatic action on neoplasm, including endocrine t...

ea0035p904 | Pituitary Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2014

Alternative method of macroprolactin evaluation as a cause of hyperprolactinaemia

Beda-Maluga Karolina , Pisarek Hanna , Swietoslawski Jacek , Fuss-Chmielewska Julita , Winczyk Katarzyna

Introduction: Macroforms of prolactin (PRL), the most often macroprolactin (MaPRL), may be the cause of about 25% cases of laboratory diagnosed hyperprolactinaemia. Macroprolactin is usually quantified by polyethylene glycol precipitation, however, the cut-off value (that means the calculated recovery ratio of monomeric PRL) has not been precisely determined and has rather unsatisfactory diagnostic specificity. Therefore, it is suggested that the evaluation of hyperprolactinae...