Searchable abstracts of presentations at key conferences in endocrinology

ea0015s25 | Androgen receptors - physiology and disease | SFEBES2008

Tissue-specific androgen receptor knockout models. novel tools in the study of androgen action

Verhoeven Guido , Denolet Evi , Swinnen Johannes , Saunders Philippa , Sharpe Richard , De Gendt Karel

Specific ablation of the androgen receptor (AR) in selected target cells prevents the major developmental defects inherent to generalised AR inactivation (Tfm, ARKO) and allows a detailed analysis of the contribution of defined cells and molecular pathways to more complex effects of androgens. We successfully applied this approach in the study of the role of androgens in the control of spermatogenesis, by developing a Cre/loxP-based mouse model with a Sertoli cell (SC)-selecti...