Searchable abstracts of presentations at key conferences in endocrinology

ea0025p346 | Thyroid | SFEBES2011

Changes in urinary fractional excretion (FE) of calcium and phosphate following treatment of hyperthyroid cats

Williams Tim , Elliott Jonathan , Syme Harriet

Hyperthyroid cats have elevated parathyroid hormone (PTH) concentrations and suppressed fibroblast growth factor-23 (FGF-23) concentrations, both of which normalise following treatment of hyperthyroidism. PTH, FGF-23, and thyroid hormone can influence the renal reabsorption of calcium and phosphate. The aim of the present study was to assess the influence of hyperthyroidism on renal tubular function in cats indirectly, by comparing the FE of electrolytes in hyperthyroid cats w...

ea0013p315 | Thyroid | SFEBES2007

Subclinical hyperthyroidism in cats

Wakeling Jennifer , Elliott Jonathan , Syme Harriet

Cats are the only species, other than humans, in which naturally occurring, non-malignant hyperthyroidism has been recorded. Feline hyperthyroidism has many similarities to toxic nodular goitre, including age at risk, presentation, histological features and similar ‘switch-on’ mutations of the TSH receptor and linked G-proteins. Subclinical hyperthyroidism is well recognised in humans but has only recently been described in cats. We present preliminary data from a pr...

ea0031p329 | Steroids | SFEBES2013

P450 side-chain cleavage enzyme autoantibodies in canine Addison's disease

Boag Alisdair , McLaughlin Kerry , Christie Mike , Graham Peter , Syme Harriet , Catchpole Brian

Background: Addison’s disease (AD) in both humans and dogs is characterised by corticosteroid deficiency requiring lifelong hormone therapy. In humans autoimmune pathogenesis is established; at diagnosis ~90% of patients are 21-hydroxylase (21-OH) autoantibody positive, with antibodies to other adrenal antigens also detected. The pathogenesis of canine AD is less well characterised; autoimmune mechanisms are suspected, with anti-adrenal autoantibodies demonstrated by indi...