Searchable abstracts of presentations at key conferences in endocrinology

ea0019p317 | Steroids | SFEBES2009

Cofactors and modify Cofactors and modifications of the glucocorticoid receptor

Davies L , Gkourtza A , Symeou C , Lynch J , Taylor S , Demonacos C , Krstic-Demonacos M

The glucocorticoid receptor (GR) is a member of the nuclear hormone receptor superfamily that acts as a hormone responsive transcription factor. GR function is controlled by hormone binding, post-translational modifications and through interaction with cofactors. Here, we report that JNK dependent phosphorylation of GR affects its sumoylation. JNK activation by UV radiation that targets GR for phosphorylation at serine 246 (S246) facilitated subsequent GR sumoylation at lysine...