Searchable abstracts of presentations at key conferences in endocrinology

ea0056gp143 | Neuroendocrinology | ECE2018

Characterization and functional rescue of a nephrogenic diabetes insipidus causing S127F substitution in V2 vasopressin receptor

Erdelyi Laszlo , Szalai Laura , Sziraki Andras , Balla Andras , Hunyady Laszlo

The concentrating function of the kidney is important to maintain the water homeostasis of the body. It is regulated by the arginine-vasopressin system through the type 2 vasopressin receptor (V2R). Loss-of-function mutations of V2R in kidney can lead to nephrogenic diabetes insipidus (NDI) which results several symptoms such as polyuria, polydipsia, and hyposthenuria. In this study, we functionally characterized and investigated the potential rescue of a missense mutation (S1...

ea0063p1014 | Interdisciplinary Endocrinology 2 | ECE2019

Characterization of type 1 angiotensin II receptor activation induced gene expression changes in rat vascular smooth muscle cells

Szalai Laura , Porkolab Edit , Szakadati Gyongyi , Gem Janka , Kovacs Kinga , Balla Andras , Hunyady Laszlo

Angiotensin II (AngII) mainly acts through type 1 angiotensin II receptor (AT1R) to promote a broad variety of biological effects. The vascular smooth muscle cells are one of the main target of AngII and its stimulation activates numerous signaling pathways which could result in gene expression changes in these cells. We carried out Affymetrix GeneChip experiments to analyze the effects of AngII stimulation on gene expression. More than 200 genes were upregulated in response t...

ea0070aep7 | Adrenal and Cardiovascular Endocrinology | ECE2020

Investigation of angiotensin II induced gene expression changes in vascular smooth muscle cells

Balla András , Szalai Laura , Gém Janka , Kovács Kinga , Szakadáti Gyöngyi , Hunyady László

The angiotensin II (AngII) hormone exerts a number of biological effects through the type 1 angiotensin II receptor (AT1R). One of the main targets of AngII are vascular smooth muscle cells, their stimulation activates many signaling pathways and results in gene expression changes.Affymetrix Gene Chip experiments were performed to analyze the effects of AngII stimulation on gene expression. For the determinations, aortic thoracic aorta from young male Wi...