Searchable abstracts of presentations at key conferences in endocrinology

ea0014p586 | (1) | ECE2007

The role of G-protein- and β-arrestin dependent signaling mechanisms in the tonic regulation of prolactin secretion

Oláh Márk , Szepesi Zsuzsanna , Bodnár Ibolya , Nagy György M. , Tidrenczel Zsolt

It is well known that hypophyseotrophic dopamine (DA) exhibits a tonic inhibitory effect on pituitary lactotrops in vivo. We have previously observed that prolactin (PRL) cells obtained from lactating rats become partially resistant to DA following a brief suckling period compared to non-suckled control female rats. This, so-called “desensitization” (and a parallel appearance of “tolerance”) to DA is mediated through by a selective change of protein phospha...