Searchable abstracts of presentations at key conferences in endocrinology

ea0003oc18 | Growth Regulation | BES2002

Overexpression of insulin-like growth factor binding protein-5 (IGFBP-5) induces severe growth retardation in transgenic mice

Salih D , Szestak T , Carter E , Gonzalez I , Eisemann J , Pell J

IGFBP-5 is the most conserved of a family of high affinity proteins that modulate IGF activity. It is upregulated in key lineages during their differentiation and development. In addition to domains associated with IGF binding, IGFBP-5 also possesses motifs that may be involved with its recently demonstrated IGF-independent actions. We have therefore examined the hypothesis that IGFBP-5 is important during development. We have generated mice overexpressing IGFBP-5 using an ear...