Searchable abstracts of presentations at key conferences in endocrinology

ea0014s3.1 | Signaling and regulation of G-protein-coupled hormone receptors | ECE2007

Trafficking and signaling of angiotensin receptors

Hunyady László , Karip Eszter , Turu Gábor , Szidonya László

The octapeptide hormone angiotensin II (Ang II) exerts its major biological effects via angiotensin AT1 receptors (AT1Rs). Signaling of AT1Rs is regulated by ß-arrestins, which bind to activated AT1Rs, uncouple them form G proteins, and initiate their internalization via clathrin-coated pits and cause G protein independent MAP kinase activation. It has been shown previously that AT1Rs internalize via ß-arrestin-d...