Searchable abstracts of presentations at key conferences in endocrinology

ea0063p711 | Pituitary and Neuroendocrinology 2 | ECE2019

Whole genome demethylation status of somatic DNA extracted from different pituitary adenoma types

Szabo Borbala , Nemeth Kinga , Meszaros Katalin , Szucs Nikolett , Czirjak Sandor , Reiniger Lilla , Patocs Attila , Butz Henriett

Background: Although the role of hypermethylation of certain tumor suppressor genes are known in pituitary adenomas little information is available regarding whole methylation-demethylation status and especially regarding its correlation with clinical parameters. High-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) is an easy and accurate method to detect the level of methylcytosine (5 mC) and the demethylation intermedier hydroxymethylcytosine (5 hmC) ...

ea0037ep67 | Adrenal cortex | ECE2015

Glucocorticoid receptor polymorphisms not affect the therapy efficiency in adult, Hungarian patients with 21-hydroxylase deficiency

Klara Koncz , Abigel Farkas , Marton Doleaschall , Nikolett Szucs , Miklos Toth , Peter Igaz , Karoly Racz , Attila Patocs

Background: Congenital adrenal hyperplasia (CAH) is an autosomal recessive inherited disorder caused by 21-hydroxylase deficiency in 95% of all cases. Two main clinical subtypes: the classical (manifested after birth, or in early newborn period) and the late onset (LO) phenotype (manifested commonly during puberty). The lifelong glucocorticoid (GC) supplementation is essential in therapy of these patients. Response to GC therapy is individual and partly genetically determined....

ea0022p32 | Adrenal | ECE2010

Utility of midnight salivary cortisol measurement in the diagnosis of overt and subclinical Cushing's syndrome

Sereg Marta , Toke Judit , Patocs Attila , Igaz Peter , Szucs Nikolett , Varga Ibolya , Szappanos Agnes , Glaz Edit , Racz Karoly , Toth Miklos

Background: Midnight salivary cortisol (SalC2400) measurement has been recently suggested as one of the first-line screening tests for hypercortisolism.Aims: In our present study, we evaluated the clinical utility of the salivary cortisol (SalC) measurement in the diagnosis of both overt and subclinical CushingÂ’s syndrome.Patients and methods: Patients with overt CushingÂ’s syndrome (n=23, group A) and those with su...