Searchable abstracts of presentations at key conferences in endocrinology

ea0004oc17 | Steroid hormone action | SFE2002

Evidence from co-culture studies that annexin 1 serves as a paracrine mediator of glucocorticoid action between folliculo-stellate cells and corticotrophs

Tierney T , Christian H , Morris J , Buckingham J

Annexin 1 (ANXA1) plays an essential role in the 'early-delayed' feedback effects of glucocorticoids (GCs) on ACTH release. Evidence that ANXA1 is externalised from pituitary cells in response to GCs, together with the finding that the protein is localised mainly to the folliculo-stellate (FS) cells, has led us to propose that ANXA1 is a paracrine mediator of GC action in the anterior pituitary. To address this hypothesis we have examined ANXA1-dependent GC actions in co-cultu...

ea0008oc12 | Neuroendocrinology and Reproduction | SFE2004

Macrophage migration inhibitory factor is released from pituitary folliculo-stellate-like cells by endotoxin and dexamethasone and attenuates the steroid-induced inhibition of interleukin 6 release

Tierney T , Patel R , Stead CS , Leng L , Bucala R , Buckingham JC

Macrophage migration inhibitory factor (MIF) is a pro-inflammatory cytokine produced by peripheral immune cells and also by pituitary endocrine cells. MIF exerts its pro-inflammatory actions in the host defence system by blocking the inhibitory effects of glucocorticoids on the release of other pro-inflammatory cytokines. Reports that pituitary folliculo-stellate (FS) cells show characteristics of immune cells led us to propose that FS cells may serve as an additional source o...