Searchable abstracts of presentations at key conferences in endocrinology

ea0008p44 | Endocrine Tumours and Neoplasia | SFE2004

Expression of Bone Morphogenetic Protein receptors in human pituitary adenomas

Brown PL , Stoddart HL , Sidhu KK , Milligan TP , Burrin JM

Bone morphogenetic proteins (BMPs) regulate growth, differentiation and apoptosis in a variety of tissues and have crucial roles in the regulation of reproduction. BMPs bind specific Type II receptors and form complexes with Type I receptors (Alk2, 3 or 6) whereby the Type II receptors activate Type I receptors by phosphorylation. BMP2 and 4 play a crucial role in the development of the gonadotroph cell lineage during mouse pituitary morphogenesis and BMP6, 7, and 15 stimulate...

ea0012oc7 | Young Endocrinologist prize session | SFE2006

T3 stimulation of MAP kinase and cell proliferation in human osteoblast-like cells is initiated at integrin αVβ3

Scarlett AL , Parsons MP , Hanson PL , Sidhu KK , Milligan TP , Burrin JM

T3 and T4 rapidly activate intracellular signalling cascades via thyroid hormone receptor (TR)-independent actions, suggesting the existence of a plasma membrane receptor. Recent studies support a role for the RGD recognition site of integrin, a transmembrane glycoprotein, as a cell surface TR. We have demonstrated, using PCR and Western blotting, the expression of integrin αVβ3 mRNA and protein in the transformed human osteosarcoma cell line MG...