Endocrine Abstracts

Background: Rabson Mendenhall Syndrome (RMS) is a rare genetic syndrome that is caused by the mutation in the insulin receptor gene. Such mutation consequently results in severe insulin resistance. Patients suffering from RMS develop constant hyperglycemia from a progressive decline of endogenous insulin secretion. Drug therapy for RMS includes metformin, pioglitazones, large doses of insulin alongwith recombinant human methionyl leptin or IGF-1. Here we describe a case of RMS...

Background: Acromegaly is due to excess Growth hormone (GH) production, usually as result of pituitary adenoma. The diagnosis is often preceded by around 5 years of active but unrecognized disease. Clinical expression of the disease in each patient depend on the levels of GH and Insulin-like Growth Factor-1 (IGF-1), age, tumor size, and the delay in diagnosis. Successful remission after Trans-sphenoidal surgery (TSS) is reported to be found in 52.5% of cases in the developed c...

Background: Primary hyperparathyroidism (PHPT) is characterized by abnormal regulation of PTH secretion by calcium. The most common clinical presentation of PHPT is asymptomatic (80% cases), followed less likely by the classical symptoms of bones, stones, abdominal moans, and psychic groans. The diagnosis of PHPT is usually first suspected because of the finding of an elevated serum calcium concentration along with a rise in Parathyroid hormone (PTH) level. Serum phosphorus le...

Introduction: Ectopic thyroid tissue is the most common form of thyroid dysgenesis. But primary malignant transformation in ectopic thyroid tissue is quite a rare entity, with follicular malignancy being the dominant form at ectopic sites. Very infrequently, malignant ectopic thyroid tissue can present with metastasis to lymph nodes. But we report a case of malignant ectopic thyroid tissue over manubrium sterni with distant metastasis.Case presentation: ...