Endocrine Abstracts

Presentation and investigation: A 10-month-old girl presented with a bluish lump on the left side of her abdomen which was increasing in size. An abdominal mass was palpable on examination. An ultrasound showed a large, partly calcified mass measuring 9×6×9 cm arising from the left adrenal gland. There were also calcified lesions in her liver and lungs suggesting metastsis. MRI confirmed the ultrasound finding plus detected an intraspinal deposit with some cord compr...

Aims: To assess the relationship between thyroid peroxidase (TPO) antibodies and the development of thyroid disorders in children with type 1 diabetes mellitus (T1DM).Method: TPO antibody status and duration of diabetes at diagnosis of thyroid disorder were cross-sectionally examined in all children attending the Oxford T1DM service (n=342, male:female ratio 1:0.8).Results: Twenty patients were identified with thyroid como...

Introduction: Pancreatogenic diabetes (Type 3c diabetes-T3cDM) is rare in children, and frequently underdiagnosed. The prevalence is 5–10% of all adult diabetes cases in the developed world. Over 78% of people with T3cDM have chronic pancreatitis.Case: A 15-year old presented with polyuria, polydipsia, abdominal pain, weight loss (WL) and a three-generational family history of type-1 (T1DM) and type-2 diabetes mellitus (T2DM). Examination revealed m...

Background: There is growing recognition of the importance of sports/exercise in children and young people (CYP) with type 1 diabetes (T1DM) [NICE guidance 1.2.47–1.2.53]. In 2014 our Paediatric Diabetes service set up a Diabetes Sports clinic run by a paediatric diabetologist and dietician and an adult diabetologist. Appointments were offered to families of CYP with T1DM who are ‘elite sportspersons’–performing at competitive levels, or regional/national l...

Objectives: Recently updated NICE guidelines (2015) on coeliac screening for children with Type 1 diabetes mellitus (T1DM) recommend just one initial screen for coeliac disease (CD) at the time of T1DM diagnosis and thereafter only if symptomatic. This is in contrast to the recommendation for on-going annual screening for autoimmune thyroid disease (ATD). Our unit has historically performed annual screening for both ATD and CD. Our study aimed to establish whe...

Introduction: Children with Down syndrome (trisomy-21/T21) are at risk of developing congenital and early (diagnosed ≤1 year) hypothyroidism. Our current monitoring follows the Down Syndrome Medical Interest Group (DSMIG) guidance: performing thyroid function tests (TFT) at birth and 12 months.Aims/objectives: 1) Determine the incidence of congenital/early hypothyroidism in babies with T21 and determine long-term thyroid function outcomes (by age 4...

Background: A 5-month-old girl presented with a history of acute abdominal distension over several weeks. Three weeks previously she had developed pubic hair, and some early breast development. The GP had reassured parents on two occasions that this was normal. On examination she had Tanner breast stage 3 bilaterally, pubic hair stage 3, mild cliteromegaly, and gross abdominal distension.Investigations: An ultrasound scan revealed a massively enlarged ri...

There is growing recognition within Endocrinology physician and patient groups of morbidity and mortality in association with prescribing errors and dysnatraemia, in hospitalised patients with cranial diabetes insipidus (CDI). The study had two aims; firstly, to assess outcomes in hospitalised patients (paediatric and adult) with CDI by review of electronic records from 2012-2021, and secondly, to assess the same patient cohort’s perceptions of their care via telephone qu...

Background: Neonatal cortisol assessment is indicated in suspected adrenal insufficiency.Aims/objectives: Review of neonatal cortisol assessment within our Trust over seven years, to analyse trends, indications, outcomes; and relationships between gestational age (GA), birth weight (BW) and cortisol assessment.Methodology: From cortisol results on neonates (≤30 days age) between 2012–2018 (inclusive) we identified random...

Introduction: The importance of good transition care has been highlighted by NICE and NHSI. Over the last 5 year we have focused on transforming our endocrine transition service.Background: Our centre took part in the BSPED/BES-led 2014 National Adolescent Care and Transition Audit of Young people with Hormone Conditions. From this we identified key areas for service improvement including: families wanted to establish a better relationship with and have ...